The Italian Journal of Neurological Sciences

, Volume 2, Issue 1, pp 81–84 | Cite as

Epidemiology of Duchenne muscular dystrophy in the province of Turin

  • Bertolotto A. 
  • Marchi M. De 
  • Doriguzzi C. 
  • Mongini T. 
  • Monnier C. 
  • Palmucci L. 
  • Schiffer D. 
  • Verzé L. 
Original Articles

Abstract

An epidemiological investigation on Duchenne muscular dystrophy in Turin and its province has been carried out for the period 1955–1974. The incidence of the disease proved to be 24×10−5, and the prevalence 2.15×10−5. The mutation rate was 80×10−6. The data are compared with the literature. Segregation analysis on many families was performed in order to find the theoretical number of carrier among Duchenne mothers. The importance of epidemiology for genetic counselling is stressed.

Key-Words

Epidemiology Duchenne dystrophy segregation analysis 

Sommario

È stata condotta un'indagine epidemiologica della DMP tipo Duchenne in Torino e provincia, considerando il periodo 1955–1974. L'incidenza della malattia è risultata di 24×10−5, la prevalenza di 2.15×10−5. Il tasso di mutazione è di 80×10−6. I dati sono discussi e paragonati con quelli della letteratura. Alcune famiglie sono state sottoposte and analisi di segregazione per identifiÇare il numero teorico di portatrici tra le madri Duchenne. Viene sottolineata l'importanza dell'epidemiologia in vista del genetic counselling.

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Copyright information

© Masson Italia Editori 1981

Authors and Affiliations

  • Bertolotto A. 
    • 2
  • Marchi M. De 
    • 2
  • Doriguzzi C. 
    • 1
  • Mongini T. 
    • 1
  • Monnier C. 
    • 1
  • Palmucci L. 
    • 1
  • Schiffer D. 
    • 1
  • Verzé L. 
    • 1
  1. 1.Clinica Neurologica IICentro per le Malattie NeuromuscolariTorino(Italy)
  2. 2.Istituto di Genetica MedicaUniversità di TorinoTorino(Italy)

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