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Die Wirkung von Heparin in der Regulierung des Wasser- und Elektrolythaushaltes

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Zusammenfassung

Chronische Heparinbehandlung führte bei Patienten mit kardialem Ödem zu einer signifikanten Steigerung der Natrium-, Kalium- und Urinausscheidung. Dieser Effekt war auch bei Versuchspersonen ohne Ödemkrankheiten nachweisbar. Die Ausscheidung von neutralen 17-Ketosteroiden (in mg/24 Std) ging unter der Heparinbehandlung zurück. Die Entwicklung einer heparinähnlichen Substanz ohne wesentliche gerinnungshemmende Wirkung dürfte für die Behandlung von Ödemzuständen von Wert sein.

Summary

Heparin treatment increased significantly the urinary output of sodium, potassium and water in patients suffering from heart failure with oedema and in patients without any signs of heart failure or oedema also. The heparin treatment decreased the urinary excretion of total neutral 17-ketosteroids (mg/24 hours) both in women and men. The development of an heparin-like polysaccharide without strong anticoagulant activity might be of value in treatment of oedematous states.

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Literatur

  1. Allen, W. M.: A simple method for analyzing complicated absorption curves of use in the colorimetric determinations of urinary steroids. J. clin. Endocr.10, 71–83 (1950).

    CAS  Google Scholar 

  2. Cejka, V., L. A. de Vries, M. E. Smorenberg-Schoorl, J. J. van Daatselaar, J. G. G. Borst, andC. L. H. Majoor: Effect of heparinoid and spirolactone on the renal excretion of sodium and aldosterone. Lancet1960 I, 317–319.

    Google Scholar 

  3. Engelberg, H., J. Gofman, andH. Jones: Diabetes1, 425 (1952).

    CAS  PubMed  Google Scholar 

  4. Fachet, J., E. Stark, K. Vallent, andM. Palkovits: Some observations on the functional interrelationship between the thymus and the adrenal cortex. Acta med. Acad. Sci. hung.18, 461–467 (1962).

    CAS  Google Scholar 

  5. Hamburger, C.: Normal urinary excretion of neutral 17-ketosteroids with special to age and sex variations. Acta endocr. (Kbh.)1, 19 (1948).

    CAS  Google Scholar 

  6. Kittinger, G. W., B. C. Wexler, andB. F. Miller: Effect of Aldosterone antagonist on in vitro production of aldosterone and corticosterone in rats. Proc. Soc. exp. Biol. (N.Y.)105, 394 (1960).

    CAS  Google Scholar 

  7. Majoor, C. L. H., H. Prenen, P. J. J. van Munster, andR. J. A. F. M. Schlatmann: Zit. in:C. L. H. Majoor, R. J. A. F. M. Schlatmann, A. P. Jansen, andH. Prenen, Water and electrolyte metabolism. Excretion pattern and mechanism of diuresis induced by heparin. Proc. of the Symposium on water and electrolyte metabolism (ed.C. P. Stewart andTh. Strengers), Amsterdam: Elsevier Publ. Co. 1960.

    Google Scholar 

  8. Majoor, C. L. H., R. J. A. F. M. Schlatmann, A. P. Jansen, andH. Prenen: Excretion pattern and mechanism of diuresis induced by heparin. In: Water and electrolyte metabolism. Proc. of the Symposium on water and electrolyte metabolism (ed.C. P. Steward andTh. Strengers), Amsterdam: Elsevier Publ. Co. 1960.

    Google Scholar 

  9. Majoor, C. L. H., R. J. A. F. M. Schlatmann, A. P. Jansen, andH. Prenen: Excretion pattern and mechanism of diuresis induced by heparin. Clin. chim. Acta5, 591–606 (1960).

    Article  CAS  PubMed  Google Scholar 

  10. McLean: The thromboplastic action of cephalin. Amer. J. Physiol.41, 250 (1916).

    Google Scholar 

  11. Rajnaud, R., J. R. Eshougues, P. Pasquet, andE. Karoubi: Zit. in:C. L. H. Majoor, R. J. A. F. M. Schlatmann, A. P. Jansen, andH. Prenen, Excretion pattern and mechanism of diuresis induced by heparin. In: Water and electrolyte metabolism. Proc. of the Symposium on water and electrolyte metabolism, (ed.C. P. Stewart andTh. Strengers), Amsterdam: Elsevier Publ. Co. 1960.

    Google Scholar 

  12. Schlatmann, R. J. A. F. M., H. Prenen, A. P. Jansen, andC. L. H. Majoor: The natriuretic action of heparin and some related substances. Lancet1960 I, 314–317.

    Google Scholar 

  13. Zimmermann, W.: Chemische Bestimmungs-methoden von Steroidhormonen in Körperflüssigkeiten, p. 63. Berlin-Göttingen-Heidelberg: Springer 1955.

    Google Scholar 

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Authors and Affiliations

  1. Aus der I. Chirurgischen Universitätsklinik, Hungary

    K. Vallent & J. Fachet

  2. der pathophysiologischen Abteilung des Medizinisch-Experimentellen Forschungsinstitutes der Ungarischen Akademie für Wissenschaften, Hungary

    K. Vallent & J. Fachet

Authors
  1. K. Vallent
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  2. J. Fachet
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Vallent, K., Fachet, J. Die Wirkung von Heparin in der Regulierung des Wasser- und Elektrolythaushaltes. Klin Wochenschr 43, 235–240 (1965). https://doi.org/10.1007/BF02350865

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  • DOI: https://doi.org/10.1007/BF02350865

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