Journal of Infection and Chemotherapy

, Volume 1, Issue 3, pp 190–192 | Cite as

Herpesvirus-like DNA sequences in Japanese patients with AIDS-related kaposi's sarcoma

  • Natsuo Tachikawa
  • Mieko Goto
  • Hiroyuki Gatanaga
  • Harutaka Katano
  • Shinichi Oka
  • Tomo Wakabayashi
  • Shigeo Mori
  • Aikichi Iwamoto
Note

Abstract

The cause and origin of Kaposi's sarcoma (KS) remain an enigma. Recently, Chang et al. reported a DNA fragment resembling human gamma herpesvirus that was specifically associated with KS tissue. In this paper, we report examination of three Japanese patients for presence of the KS-associated herpesvirus-like (KSHV) sequences. KSHV sequences were present in two of these patients, but could not be confirmed in the third because of DNA degradation. The KSHV sequences appeared to be present mainly in those tissues with KS invasion. Our results further demonstrate the presence of KSHV in KS lesions and support its role in the pathogenesis of KS.

Keywords

Kaposi's sarcoma herpesvirus-like DNA sequences AIDS 

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Copyright information

© Japan Society of Chemotherapy/Chirchill Livingstone Japhan 1996

Authors and Affiliations

  • Natsuo Tachikawa
    • 1
  • Mieko Goto
    • 1
  • Hiroyuki Gatanaga
    • 1
  • Harutaka Katano
    • 2
  • Shinichi Oka
    • 1
  • Tomo Wakabayashi
    • 3
  • Shigeo Mori
    • 2
  • Aikichi Iwamoto
    • 1
  1. 1.Department of Infectious Diseases, Institute of Medical ScienceUniversity of TokyoTokyoJapan
  2. 2.Department of Pathology, Institute of Medical ScienceUniversity of TokyoTokyoJapan
  3. 3.Department of Laboratory Medicine, Institute of Medical ScienceUniversity of TokyoTokyoJapan

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