Journal of Radioanalytical and Nuclear Chemistry

, Volume 239, Issue 2, pp 385–389 | Cite as

Synthesis of186Re-DMSA and its biodistributions in mice

  • N. Nogawa
  • S. Momose
  • K. Miyazawa
  • Y. Makide
  • K. Oohashi
  • K. Hashimoto
  • N. Morikawa
Life Science

Abstract

Optimum conditions were determined for high-yield synthesis of186Re- and188Re-meso-2, 3-dimercaptosuccinic acid complexes applicable to animal injection. The yield was more than 95% under the conditions used. The bone accumulation of the complexes was remarkable in the biodistributions in mice.

Keywords

Physical Chemistry Inorganic Chemistry Optimum Condition Acid Complex Bone Accumulation 

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Copyright information

© Akadémiai Kiadó 1999

Authors and Affiliations

  • N. Nogawa
    • 1
  • S. Momose
    • 2
  • K. Miyazawa
    • 2
  • Y. Makide
    • 1
  • K. Oohashi
    • 2
  • K. Hashimoto
    • 3
  • N. Morikawa
    • 1
  1. 1.Radioisotope CenterThe University of TokyoTokyoJapan
  2. 2.Laboratory of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical SciencesChiba UniversityChiba-shiJapan
  3. 3.Japan Atomic Energy Research InstituteTokai-mura, Ibaraki-kenJapan

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