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Quality control and clinical application of two bone imaging99mTc radiopharmaceuticals

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Abstract

The radiochemical purity of MDP and HEDP has been determined by means of gel chromatography on Sephadex and thin layer chromatography on plastic foil silica gel. The comparison of the two radiopharmaceuticals shows equal level of complex formation with99mTc. The biodistribution demonstrated that the application of HEDP allows earlier scanning than MDP. MDP and HEDP show equal effectivity during the clinical investigations. There is no significant difference in the radiochemical purity within six hours after the reconstitution of the freeze-dried kits. HEDP kit demonstrates shorter period of accumulation and equivalent complex formation levels, so it can be used in routine nuclear medicine diagnostics together with MDP kit.

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Authors and Affiliations

  1. Institute for Nuclear Research and Nuclear Energy, Sofia, Bulgaria

    M. Ayranov, A. Strezov & A. Jordanova

  2. National Oncological Centre, Sofia, Bulgaria

    E. Piperkova & S. Sergieva

Authors
  1. M. Ayranov
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  2. A. Strezov
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  3. A. Jordanova
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  4. E. Piperkova
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  5. S. Sergieva
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Ayranov, M., Strezov, A., Jordanova, A. et al. Quality control and clinical application of two bone imaging99mTc radiopharmaceuticals. J Radioanal Nucl Chem 240, 349–352 (1999). https://doi.org/10.1007/BF02349177

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  • DOI: https://doi.org/10.1007/BF02349177

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