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New99mTc-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging

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Abstract

A new diiodine substituted IDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with99mTc. It was established that99mTc-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on99mTc-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for99mTc-SOLCOIODIDA. Related to99mTc-SOLCOIODIDA,99mTc-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of99mTc-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of99mTc-SOLCOIODIDA has been reduced for about 60%. The protein binding of99mTc-DIIODIDA and99mTc-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that99mTc-DIIODIDA hepatobiliary imaging agent is superior to the presently used99mTc-monoiodine IDA derivatives.

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Authors and Affiliations

  1. Laboratory for Radioisotopes, Vinča Institute of Nuclear Sciences, P. O. Box 522, 11001, Belgrade, Yugoslavia

    M. S. Jovanović, B. Zmbova & LJ. Vuksanović

  2. Faculty of Pharmacy, University of Belgrade, Yugoslavia

    J. Brborić, S. Vladimirov & D. Živanov-Stakić

  3. Clinical Centre of Serbia, Institute of Nuclear Medicine, Belgrade, Yugoslavia

    V. Obradović

Authors
  1. M. S. Jovanović
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  2. J. Brborić
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  3. S. Vladimirov
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  4. B. Zmbova
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  5. LJ. Vuksanović
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  6. D. Živanov-Stakić
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  7. V. Obradović
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Jovanović, M.S., Brborić, J., Vladimirov, S. et al. New99mTc-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. J Radioanal Nucl Chem 240, 321–324 (1999). https://doi.org/10.1007/BF02349171

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  • DOI: https://doi.org/10.1007/BF02349171

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