Abstract
Radioiodination of meta-iodobenzylguanidine (MIBG) by the isotopic exchange technique in the dry state has been performed. Benzoic acid, pivalic acid and acetamide have been used as molten protic media to promote isotopic exchange reactions. Ammonium sulphate, diammonium hydrogen ortho-phosphate and ammonium chloride were used as catalysts which provide acidic media to facilitate exchange reactions. Maximum radiochemical yields of 97.1±1.3% and 84.3±1.6% [131I] MIBG were obtained when ammonium sulphate and benzoic acid were used. High radiochemical yields of 88.3±1.1% and 74.4±1.5% [131I] MIBG were also obtained in case of diammonium hydrogen orthophosphate and pivalic acid which suggests their successful use as reaction media in the radioiodination of MIBG. The activation energy for the exchange reaction in ammonium sulphate was calculated to be 10.8 kcal/mole.
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D. D. Mosley, C. K. Kim et al. J. Nucl. Med., 35 (1994) 1138.
S. Maurea, S. Lastoria et al. J. Nucl. Med., 35 (1994) 1429.
L. C. Campbell, Australian and New Zealand J. Med., 26 (1996) 754.
M. Gelfand, R. E. Marris, J. Nucl. Med., 35 (1994) 1753.
S. Fukuoka, K. Hayashida, Y. Hirose et al. Eur. J. Nucl. Med., 24 (1997) 523.
K. Kohnert, H. Lerch, M. Thelen et al., Nucl. Med. 35 (1996) 220.
T. J. Mangner, J. L. Wu, D. M. Wielend, W. H. Beierwaltes, J. Nucl. Med., 22 (1981) 12.
T. J. Mangner, J. L. Wu, D. M. Wielend, J. Org. Chem., 47 (1982) 1484.
B. H. Mock, R. E. Weiner, J. Appl. Radiation Isotopes, 39 (1988) 939.
R. F. Verbruggen, Appl. Radiation Isotopes, 38 (1987) 303.
G. Wollny, U. Welzel, Isotopenpraxis, 26 (1990) 150.
T. Russouw, Appl. Radiation Isotopes, 43 (1991) 1301.
H. Dougan, D. M. Lyster, J. S. Vincent et al., J. Labelled Comp. Radiopharm., 25 (1988) 531.
M. Neves, A. Paulo, L. Patricios, Appl. Radiation Isotopes, 43 (1992) 737.
D. Chen, X. Jin, Y. Liu et al., J. Radioanal. Nucl. Chem., 206 (1996) 37.
L. Najdovski, ANZ-Nuclear Medicine, 27 (1996) 32.
A. Mansouri, B. Saada, A. Benzaid, J. Labelled Compd. Radiopharm., 32 (1993) 347.
G. El-Shaboury, M. T. El-Kolaly, N. Zakarie, S. El-Bayoumy, M. Raieh, 6th Conf. of Nuclear Sciences and Applications, Vol. 3, Cairo, 15–20 March, 1996, p. 163.
G. Vaidyanathan, M. R. Zalutsky, Appl. Radiation Isotopes, 44 (1993) 621.
R. M. Lambrecht, H. Atkins, H. Elias, J. S. Fowler, S. S. Lins, A. P. Wolf, J. Nucl. Med., 15 (1974) 863.
D. M. Wieland, J. Wu, L. E. Brown, T. S. Mangner et al., Nucl. Med., 21 (1980) 349.
H. Elias, C. Arnold, G. Kloss, Intern. J. Appl. Radiation Isotopes, 24 (1973) 463.
H. Elias, H. F. Lotterhos, Chem. Ber., 109 (1976) 1580.
M. Eisenhut, Intern. J. Appl. Radiation Isotopes, 33 (1982) 499.
J. P. Weichert, M. E. Van Dort, M. P. Groziak, R. E. Counsell, Appl. Radiation Isotopes, 37 (1986) 907.
D. L. Fortman, P. S. Robbins, V. J. Sodd Intern. J. Appl. Radiation Isotopes, 29 (1978) 449.
C. A. Otto, H. Lee, T. S. Mangner, D. M. Wieland, Appl. Radiation Isotopes, 37 (1986) 205.
B. Lui, J. Chang, J. S. Sun, J. Billings, A. Steves, A. Ackerhalt, M. Mohnar, H. F. Kung, J. Nucl. Med., 28 (1987) 28.
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Farah, K., El-Mohty, A.A. & El-Ghany, E.A. Dry state preparation of radioiodine labeled meta-iodobenzylguanidine. J Radioanal Nucl Chem 240, 243–249 (1999). https://doi.org/10.1007/BF02349161
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DOI: https://doi.org/10.1007/BF02349161