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Journal of Infection and Chemotherapy

, Volume 1, Issue 2, pp 133–134 | Cite as

In vitro activity of twenty-three antimicrobials againstYersinia pestis strains

  • Sachiko Goto
  • Akiyoshi Tsuji
  • Teiko Murai
  • Minoru Nishida
  • Hiroko Tsukano
  • Haruo Watanabe
Note

Abstract

The microdilution method was used to determine the MICs of twenty-three antimicrobials against the 22 strains ofYersinia pestis that have been stocked in the National Institute of Health, Japan. The three fluoroquinolones, ofloxacin, ciprofloxacin and sparfloxacin, were most active, with MIC90S of 0.125 μg/ml. The cephems showed considerable differences in activity: cefdinir and cefotaxime were the most active of this group, with MIC90S of 0.25 μg/ml; they were followed by cefminox and latamoxef with MIC90S of 0.5 μg/ml. The two carbapenems tested, imipenem and panipenem, were potently active at MIC90S of 0.5 μg/ml. The study obtained MIC90S for tetracycline and doxycycline ranging from 1.0 to 2.0 μg/ml, even though these drugs are known to be clinciall active against plague. Erythromycin and clarithromycin were the least active agents.

Key words

Yersinia pestis in vitro susceptibility β-lactams aminoglycosides tetracyclines macrolides fluoroquinolones 

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Copyright information

© Japan Society of Chemotherapy/Churchill Livingstone Japan 1995

Authors and Affiliations

  • Sachiko Goto
    • 2
  • Akiyoshi Tsuji
    • 2
  • Teiko Murai
    • 2
  • Minoru Nishida
    • 2
  • Hiroko Tsukano
    • 1
  • Haruo Watanabe
    • 1
  1. 1.National Institute of HealthTokyoJapan
  2. 2.College of Health ProfessionsToho UniversityTokyoJapan

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