In vitro activity of twenty-three antimicrobials againstYersinia pestis strains
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The microdilution method was used to determine the MICs of twenty-three antimicrobials against the 22 strains ofYersinia pestis that have been stocked in the National Institute of Health, Japan. The three fluoroquinolones, ofloxacin, ciprofloxacin and sparfloxacin, were most active, with MIC90S of 0.125 μg/ml. The cephems showed considerable differences in activity: cefdinir and cefotaxime were the most active of this group, with MIC90S of 0.25 μg/ml; they were followed by cefminox and latamoxef with MIC90S of 0.5 μg/ml. The two carbapenems tested, imipenem and panipenem, were potently active at MIC90S of 0.5 μg/ml. The study obtained MIC90S for tetracycline and doxycycline ranging from 1.0 to 2.0 μg/ml, even though these drugs are known to be clinciall active against plague. Erythromycin and clarithromycin were the least active agents.
Key wordsYersinia pestis in vitro susceptibility β-lactams aminoglycosides tetracyclines macrolides fluoroquinolones
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