Conclusion
Strongyloidosis is a parasitic disease of the intestines, seen mainly in tropical areas. It is quite likely that, because its manifestations are milder than those of other tropical diseases, it may be overlooked in regions where parasitic diseases such as hookworms and roundworms are endemic. With future improvements in hygiene and the resulting decreases in parasitic diseases, increasing attention will be focused on strongyloidiasis in tropical regions — a phenomenon currently being observed in Okinawa.
Studies on the diagnosis and treatment of apparently healthy Strongyloides carriers have only just started. These studies can be expected to play a major role in improving the near-future health and welfare of people in tropical regions of the world. Parasitic diseases in Japan have a strong local character; a long-term eradication program, with due consideration to HTLV-1 infection, must be instituted.
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References
Grove DI. Strongyloidiasis, a major roundworm infection of man. New York: Taylor & Francis, 1989.
Gillim SE, Gottlieb LS. The digestive system and liver. In: Harawi SJ, O'Hara CJ (eds) Pathology and pathophysiology of AIDS and HIV-related diseases. London: Chapman & Hall Medical, 1989:327.
Shikiya K, Saito A. Strongyloidiasis. Clin Microbiol 1993;6:1011–1015 (in Japanese).
Smallman LA, Young JA, Shortland-Webb WR, Carey MP, Michael J.Strongyloides stercoralis hyperinfestation syndrome withEscherichia coli meningitis: report of two cases. J Clin Pathol 1986;39:366–370.
Boram LH, Keller KF, Justus DE, Collins JP. Strongyloidiasis in immunocompromised patients. Am J Clin Pathol 1981; 76:778–781.
Furuya N, Shimozi K, Nakamura H, Owan C, Tateyama M, Saito A, et al. A case report of meningitis and sepsis due toEnterococcus faecium complicated with strongyloidiasis. Jpn J Infect Dis 1989;63:1344–1349 (Engl abst).
Saito A. Strongyloidiasis — recent problems. Mod Med 1989;35:428–433.
Nakada K, Yamaguchi K, Furugen S, Nakasone T, Nakasone K, Oshiro Y, et al. Monoclonal integration of HTLV-1 proviral DNA in patients with strongyloidiasis. Int J Cancer 1987;40:145–148.
Petithory JC, Derouin F. AIDS and strongyloidiasis in Africa. Lancet 1987;i:921.
Zygmunt DJ.Strongyloides stercoralis. Infect Control Hosp Epidemiol 1990;11:495–497.
Koga K, Kasuya S, Khamboonruang C, Sukhavat K, Ieda M, Takatsuka N, et al. A modified agar plate method for detection ofStrongyloides stercolaris. Am Soc Trop Med Hyg 1991;518–521
Asato R, Nakasone T, Yoshida C, Arakaki T, Ikeshiro T, Murakami H. A new method to detectStrongyloides stercolaris from human stool. Jpn J Trop Med Hyg 1988;16:16–21.
Asato R, Nakasone T, Yoshida C, Arakaki T, Ikeshiro T, Murakami H, et al. Current status of Strongyloides infection in Okinawa, Japan. Jpn J Trop Med Hyg 1992; 20:169–173.
Otsuzi Y. Prevalence ofStrongyloides stercolaris infection in Kagoshima, Japan and its clinical features. Report of the Study Group of Development of New Drug for Tropical Medicine in Japanese Ministry of Welfare. pp 84–89, 1991 (in Japanese).
Igra-Siegman Y, Kapila R, Sen P, Kaminski ZC, Louria DB. Syndrome of hyperinfection withStrongyloides stercoralis. Rev Infect Dis 1981;3:397–407.
Saito A.Strongyloides stercoralis. Clin Microbiol 1990;17:607–611 (in Japanese).
Carvalho EM, Andrade TM, Andrade JA, Rocha H. Immunological features in different clinical forms of strongyloidiasis. Trans Royal Soc Trop Med Hyg 1983;77:346–349.
Genta RM, Douce RW, Walzer PD. Diagnostic implications of parasite-specific immune responses in immunocompromised patients with strongyloidiasis. J Clin Microbiol 1983;23:1099–1103.
Shikiya K, Uehara T, Uechi H, Oshira J, Arakaki T, Saito A, et al. Clinical study on ivermectin againstStrongyloides stercoralis. Jpn J Infect Dis 1991;65:1085–1090 (Engl abst).
Shikiya K, Zaha O, Niimura S, Nakamura H, Nakayoshi C, Saito A, et al. Clinical study of eradicated and resistant patients to treatment with ivermectin for strongyloidiasis. Jpn J Infect Dis 1992;66:935–943 (Engl abst).
Maayan S, Wormser GP, Widerhorn J, Sy ER, Kim YH, Ernst JA.Strongyloides stercolaris hyperinfection in a patient with the acquired immune deficiency syndrome. Am J Med 1987;83:945–948.
Saito A. Acquired immunodeficiency syndrome (AIDS) and its opportunistic infection: Strongyloides stercolaris infection. Clin Microbiol 1989;16:343–347 (in Japanese).
Miyagi J, Kinjo F, Uehara T, Kudeken N, Miyasato S, Saito A, et al. Three cases of strongyloidiasis. Clin Parasitol 1994;5:144–146 (in Japanese).
Odayo K. Two cases of strongyloidiasis with interpreted x-ray findings. Stom Intest 1989;24:1286–1290.
Uehara T, Kinjo F, Niimura S, Ishikawa T, Yonamine Y, Saito A. et al. Endoscopic findings of strongyloidiasis. Clin Parasitol 1994;5:142–143 (in Japanese).
Kinjo F, Shikiya K. Strongyloidiasis. Endosc Digest 1993;5:1621–1626 (in Japanese).
Smith B, Verghese A, Guiterrez C, Dralle W, Berk SL. Pulmonary strongyloidiasis—diagnosis by sputum gram stain. Am J Med 1985;79:663–666.
Saito A. Pulmonary strongyloidiasis Interaction to pulmonary tract and alveoli. Ther Res 1992;13:1231–1236 (in Japanese).
Cook GA, Rodoriguez H, Silva H, Rodriguez-Iturbe B. Adult respiratory distress secondary to strongyloidiasis. Chest 1987;92:1115–1116.
Sato Y, Inoue F, Matsuyama R, Shiroma Y. Immunoblot analysis of antibodies in human strongyloidiasis. Trans Royal Soc Trop Med Hyg 1990;84:403–406.
Shiroma Y, Kiyuna S, Sato Y. Clinical studies on human strongyloidiasis in Okinawa, Japan. Jpn J Parasitol 1990;39:277–283.
Sato Y, Toma H, Takara M, Shiroma Y. Application of enzyme-linked immunosorbent assay for mass examination of strongyloidiasis in Okinawa, Japan. Int J Parasitol 1990;20:1025–1029.
Arakaki T, Hasegawa H, Asato R, Ikeshiro T, Kinjo F, Saito A. A new method to detectStrongyloides stercolaris from human stool. Jpn J Trop Med Hyg 1988;16:11–17.
Arakaki T, Iwanaga M, Kinjo F, Saito A, Asato R, Ikeshiro T. Efficacy of agar-plate culture in detection ofStrongyloides stercolaris infection. J Parasitol 1990;76:425–428.
Franz KH, Schneider WJ, Pohman MH. Clinical trial with thiabendazole against intestinal nematodes infecting humans. Am J Trop Med Hyg 1965;143:383–386.
Oyakawa T, Kuniyoshi T, Arakaki T, Higashionna A, Shikiya K, Saito A, et al. New trial with thiabendazole for treatment of human strongyloidiasis. Jpn J Infect Dis 1991;65:304–310 (Engl abst).
Shikiya K, Kuniyoshi T, Higashionna A, Arakaki T, Oyakawa T, Saito A, et al. Treatment of strongyloidiasis with mebendazole and its combination with thiabendazole. Jpn J Infect Dis 1990;64:1408–1415 (Engl abst).
Shikiya K, Zaha O, Niimura S, Ikema M, Nakamura H, Saito A, et al. Long term eradication rate of mebendazole therapy for strongyloidiasis. Jpn J Infect Dis 1992;66:354–359 (Engl abst).
Shikiya K, Uechi H, Saito A, Asato R. Clinical study of mebendazole therapy for strongyloidiasis. Jpn J Med Hyg 1991;19:339–346.
Shikiya K, Kinjo N, Ikema M, Yamashiro A, Uechi H, Saito A, et al. Comparison of efficacy on powder and mebendazole in the treatment of stercolaris. Jpn J Infect Dis 1991;65:681–686 (Engl abst).
Shikiya K, Kuniyoshi T, Uechi K, et al. Treatment of strongyloidiasis with mebendazole long term eradication and new trials. Jpn J Infect Dis 1991;65:433–441 (Engl abst).
Edwards G. Pharmacokinetics of antifilarial drugs. Trop Med Parasitol 1987;38:64.
Freedman DO, Zierdt WS, Lujan A, Nutman TB. The efficacy of ivermectin in the chemotherapy of gastrointestinal helminthiasis in human. J Infect Dis 1989;159:1151.
Shikiya K, Zaha O, Niimura S, Nakamura H, Nakayoshi C, Saito A, et al. Clinical study of eradicated and resistant patients to treatment with ivermectin for strongyloidiasis. Jpn J Infect Dis 1990;66:935–943 (Engl abst).
Ette EI, Thomas WO, Achumba JI. Ivermectin: a longacting microfilaricidal agent. DIPC Ann Pharmacother 1990;24:426.
Pacoue M, Munoz B, Greene BM, White AT, Dukuly Z, Taylor HR. Safety of and compliance with communitybased ivermectin therapy. Lancet 1990;335:1377.
DeSole GD, Dadzie KW, Giese J, Remme J. Lack of adverse reactions in ivermectin treatment of onchocerciasis. Lancet 1990;335:1106.
Rothova A, Van der Lelij A, Stilma JS, Wilson WR, Barbe RF. Side effects of ivermectin in treatment of onchocerciasis. Lancet 1989;i:1439.
Lariviere M, Vingtain P, Aziz M, Beauvalis B, Weimann D, Cerouin F, et al. Double blind study of ivermectin and diethylcarbamazine on African onchocercids in patients with ocular involvement. Lancet 1990;i:174.
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Saito, A. Strongyloidiasis: Epidemiology, clinical manifestations and new methods for diagnosis and treatment. J Infect Chemother 1, 98–106 (1995). https://doi.org/10.1007/BF02348752
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DOI: https://doi.org/10.1007/BF02348752