Abstract
Approximately two-thirds of metastatic lesions that develop following curative resection of colorectal cancer occur in the liver and lung. In select groups of patients, resection of these lesions is associated with increased 5-year survival. In the liver, precise preoperative documentation of the presence, location, number, and relationship of these lesions to vascular structure is crucial in the selection of candidates for curative resection. Computed tomography with arterial portography (CTAP), intraoperative ultrasonography (IOUS), positron emission tomographic (PET) scan, and radionuclide scanning, including radiolabeled monoclonal antibody imaging, are emerging as the procedures of choice in the preoperative and intraoperative evaluation of metastatic colorectal cancer to the liver.
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Galandiuk S, Wieand HS, Moertel CG, Cha SS, Fitzgibbons RJ Jr, Pemberton JH, Wolff BG (1992) Patterns of recurrence after curative resection of carcinoma of the colon and rectum. Surg Gynecol Obstet 174:27–32
Steele G Jr, Ravikumar TS, Benotti PN (1990) New surgical treatments for recurrent colorectal cancer. Cancer 65:723–730
Benjamin IS, Blumgart LH (1988) Hepatic resection for liver metastases. Dig Dis 6:40–51
Hughes KS — Registry of Hepatic Metastases (1988) Resection of the liver for colorectal carcinoma metastases: A multi-institutional study of indications for resection. Surgery 103: 278–288
Steele G Jr, Bleday R, Mayer RJ, Lindblad A, Petrelli N, Weaver D (1991) A prospective evaluation of hepatic resection for colorectal metastases to the liver. J Clin Oncol 9:1105–1112
Steele G Jr, Ravikumar TS (1989) Resection of hepatic metastases from colorectal cancer: Biologic perspective. Ann Surg 210:127–138
Fortner JG (1988) Recurrence of colorectal cancer after hepatic resection. Am J Surg 155:378–382
Miller DL, Simmons JT, Chang R, Ward BA, Shawker TH, Doppman JL, Chang AE (1987) Hepatic metastasis detection: Comparison of three CT contrast enhancement methods. Radiology 165:785–790
Gunven P, Makuuchi M, Takayasu K, Moriyama N, Yamasaki S, Hasegawa H (1985) Preoperative imaging of liver metastases: Comparison of angiography, CT scan and ultrasonography. Ann Surg 202:573–579
Wernecke K, Rummeny E, Bongartz G, Vassallo P, Kivelitz D, Wiesmann W, Peters PE, Reers B, Reiser M, Pircher W (1991) Detection of hepatic masses in patients with carcinoma: Comparative sensitivities of sonography, CT and MR imaging. AJR 157:731–739
Ohlsson B, Tranberg KG, Lundstedt C, Ekberg H, Hederstrom E (1993) Detection of hepatic metastases in colorectal cancer: A prospective study of laboratory and imaging methods. Eur J Surg 159:275–281
Yamaguchi A, Ishida T, Nishimura G, Kanno M, Kosaka T, Yonemura Y, Izumi R, Miyazaki I, Matsui O (1991) Detection by CT during arterial portography of colorectal cancer metastases to liver. Dis Colon Rectum 34:37–40
Ferrucci JT (1990) Liver tumor imaging: Current concepts. AJR 155:473–484
Parker GA, Lawrence W Jr, Horsley S III, Neifeld JP, Cook D, Walsh J, Brewer W, Koretz MJ (1989) Intraoperative ultrasound of the liver affects operative decision making. Ann Surg 209:569–577
Machi J, Isomoto H, Yamashita Y, Kurohiji T, Shirouzu K, Kakegawa T (1987) Intraoperative ultrasonography in screening for liver metastases from colorectal cancer: Comparative accuracy with traditional procedures. Surgery 101:678–684
Soyer P, Levesque M, Elias D, Zeitoun G, Roche A (1992) Detection of liver metastases from colorectal cancer: Comparison of intraoperative US and CT during arterial portography. Radiology 183:541–544
Boldrini G, deGaetano AM, Giovanni I, Gastagneto M, Colagrande C, Castiglioni G (1987) The systemic use of operative ultrasound for detection of liver metastases during colorectal surgery. World J Surg 11:622–627
Machi J, Isomoto H, Kurohiji T, Shirouzu K, Yamashita Y, Kakegawa T, Sigel B (1986) Detection of unrecognized liver metastases from colorectal cancers by routine use of operative ultrasound. Dis Colon Rectum 29:405–409
Ward BA, Miller DL, Frank JA, Dwyer AJ, Simmons JT, Chang R, Shawker TH, Choyke P, Chang AE (1989) Prospective evaluation of hepatic imaging studies in the detection of colorectal metastases: Correlation with surgical findings. Surgery 105:180–187
Stadler J, Holscher AH, Adolf J (1991) Intraoperative ultrasonographic detection of occult liver metastases in colorectal cancer. Surg Endosc 5:36–40
Charnley RM, Morris DL, Dennison AR, Amar SS, Hardcastle JD (1991) Detection of colorectal liver metastases using intraoperative ultrasonography. Br J Surg 78:45–48
Ravikumar TS, Kane R, Cady B, Jenkins RL, McDermott W, Onik G, Clouse M, Steele G Jr (1987) Hepatic cryosurgery with intraoperative ultrasound monitoring for metastatic colon cancer. Arch Surg 122:403–409
Sugarbaker PH (1990) Surgical decision making for large bowel cancer metastatic to the liver. Radiology 174:621–626
Stewart PJ, Chu JM, Kos SC, Chapuis PH, Bokey EL (1993) Intraoperative ultrasound for the detection of hepatic metastasis from colorectal cancer. Aust NZ J Surg 63:530–534
Thomas WM, Morris DL, Hardcastle JD (1987) Contact ultrasonography in the detection of liver metastases from colorectal cancer: An in vitro study. Br J Surg 74:955–956
Makuuchi M, Hasegawa H, Yamazaki S, Takayasu K, Moriyama N (1987) The use of operative ultrasound as an aid to liver resection in patients with hepatocellular carcinoma. World J Surg 11:615–621
Makuuchi M, Hasegawa H, Yamazaki S (1987) Four new hepatectomy procedures for resection of the right hepatic vein and preservation of the inferior right hepatic vein. Surg Gynecol Obstet 164:68–72
Bismuth H, Houssin D, Castaing D (1982) Major and minor segmentectomies “re'gle'es” in liver surgery. World J Surg 6:10–24
Charnley RM, Binch C, Morris DL, Hardcastle JD (1988) Visualization of detailed hepatic anatomy by intraoperative ultrasound. Br J Radiol 61:769–770
Charnley RM, Doran J, Morris DL (1989) Cryotherapy for liver metastases: A new approach. Br J Surg 76:1040–1041
Finlay IG, McArdle CS (1986) Occult hepatic metastases in colorectal carcinoma. Br J Surg 73:732–735
Stone MD, Kane R, Bothe A Jr, Jessup M, Cady B, Steele GD Jr (1994) Intraoperative ultrasound imaging of the liver at the time of colorectal cancer resection. Arch Surg 129:431–436
Olsen AK (1990) Intraoperative ultrasonography and the detection of liver metastases in patients with colorectal cancer. Br J Surg 77:998–999
Machi J, Isomoto H, Kurohiji T, Yamashita Y, Shirouzu K, Kakegawa T, Sigel B, Zaren HA, Sariego J (1991) Accuracy of intraoperative ultrasonography in diagnosing liver metastasis from colorectal cancer: Evaluation with postoperative follow-up results. World J Surg 15:551–557
Russo A, Sparacino G, Plaja S, Cajozzo M, LaRosa C, Demma I, Bazan P (1989) Role of intraoperative ultrasound in the screening of liver metastases from colorectal carcinoma: Initial experiences. J Surg Oncol 42:249–255
Castaing RM, Amond J, Kunstlinger F, Bismuth H (1986) Utility of operative ultrasound in the surgical management of live tumors. Ann Surg 204:600–605
Goldenberg DM, Larson SM (1992) Radioimmunodetection in cancer identification. J Nucl Med 33:803–814
Larson SM (1990) Clinical radioimmunodetection, 1978–1988: Overview and suggestions for standardization of clinical trials. Cancer Res 50:92s-898s
Lind P, Lechner P, Arian-Schad K, Klimpfinger M, Cesnik H, Kammerhuber F, Eber O (1991) Anti-carcinoembryonic antigen immunoscintigraphy (Technetium-99m-monoclonal antibody BW 431/26) and serum CEA levels in patients with suspected primary and recurrent colorectal carcinoma. J Mucl Med 32(7): 1319–1325
Abdel-Nabi H, Doerr RJ, Chan HW, Balu D, Schmelter RF, Maguire RT (1990) In-111 CYT-103 immunoscintigraphy in colorectal carcinoma patients: Safety, sensitivity and preliminary clinical applications. Radiology 175:163–171
Doerr RJ, Abdel-Nabi H, Krag D, Mitchell E (1991) Radiolabeled antibody imaging in the management of colorectal cancer: Results of a multicenter clinical study. Ann Surg 214(2):118–124
Haseman MK, Brown DW, Keeling CA, Reed NL (1992) Radioimmunodetection of occult carcinoembryonic antigen producing cancer. J Nucl Med 33:1750–1757
Divgi CR, McDermott K, Johnson DK, Schnobrich KE, Finn RD, Cohen AM, Larson SM (1991) Detection of hepatic metastases from colorectal carcinoma using Indium-111 (111In) labeled monoclonal antibody (mAb): MSKCC experience with mAb111In-C1110. Int J Rad Appl Instrum [B] 18:705–710
Abdel-Nabi H, Doerr RJ (1993) Clinical applications of Indium-111 labeled monoclonal antibody imaging in colorectal cancer patients. Semin Nucl Med 13(2):99–113
Yonekura Y, Benua RS, Brill AB, Som P, Yeh SD, Kemeny NE, Fowler JW, MacGregor RR, Stamm R, Christman DR, Wolf AP (1982) Increased accumulation of 2-deoxy-2(18F)-fluoro-D-deoxyglucose in liver metastases from colon carcinoma. J Nucl Med 23:1133–1137
Strauss LG, Conti PS (1991) The applications of PET in clinical oncology. J Nucl Med 32:623–648
Hawkins RA, Choi Y, Huang S-3, Messa C, Hoh C, Phelps ME (1992) Quantitating tumor glucose metabolism with FDG and PET (Editorial). J Nucl Med 33:339–344
Okazumi S, Isono K, Enomoto K, Kikuchi T, Ozaki M, Yamamoto H, Hayashi H, Asanu T, Ryu M (1991) Evaluation of liver tumors using fluorine-18-fluorodeoxyglucose PET: Characterization of tumor and assessment of effect of treatment. J Nucl Med 33:333–339
American Cancer Society (1991) Cancer facts and figures. American Cancer Society, Atlanta
Seltzer SE, Holman BL (1989) Imaging hepatic metastases from colorectal carcinoma: Identification of candidates for partial hepatectomy. AJR 152:917–923
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Doerr, R.J., Kulaylat, M.N. & Abdel-Nabi, H. Imaging strategies in hepatic metastases from colorectal carcinoma. J Hep Bil Pancr Surg 2, 126–133 (1995). https://doi.org/10.1007/BF02348737
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DOI: https://doi.org/10.1007/BF02348737