Electron microscopic studies of primary apocrine carcinoma of the breast
- 31 Downloads
Three cases of apocrine carcinoma of the breast were investigated by light and electron microscopy. Histologically, the tumor cells were shown to have eosinophilic granular cytoplasm and occasional cytoplasmic snouts protruding into the lumen. Ultrastructurally, light and dark tumor cells were identified, and there were many lysosome-like dense bodies of various sizes and small dense granules grouped in the subapical region. Many mitochondria with incomplete cristae and numerous small vacuoles were distributed in the cytoplasm. Occasionally, intracytoplasmic lumen were visible in the tumor cells. These ultrastructural findings are quite similar to those found in normal apocrine sweat glands. However, the presence of an intraductal component of carcinoma suggests the origin to be mammary epithelial cells.
Key wordsBreast cancer Apocrine carcinoma Ultrastructure
Unable to display preview. Download preview PDF.
- 2).World Health Organization: Histological typing of breast tumors.In: International Histological Classification of Tumors, 2nd ed., p. 21, WHO, Geneva, 1981.Google Scholar
- 3).Haagensen, C.D., Bodian, C. andHaagensen, D.E., Jr.: Risk and detection.In: Breast Carcinoma, p. 103–104, W.B. Saunders, Philadelphia, 1981.Google Scholar
- 8).Bonser, G.M., Dossett, J.A. andJull, J.W.: Human and Experimental Breast Cancer, p. 298, Pitman Medical, London, 1961.Google Scholar
- 13).Dawson, K.E.: Sweat carcinoma of the breast.Edinb. Med. J. 39, 409 (1932).Google Scholar
- 14).Haagensen, C.D.: Apocrine epithelium.In: Disease of the Breast, p. 82–101, W.B. Saunders, Philadelphia, 1986.Google Scholar
- 15).Foote, F.W. andStewart, F.W.: Comparative studies of cancerous versus noncancerous breasts.Ann. Surg. 121, 6 (1945).Google Scholar