Advertisement

Medical Electron Microscopy

, Volume 27, Issue 2, pp 113–122 | Cite as

Electron microscopic studies of primary apocrine carcinoma of the breast

  • Masafumi Kurosumi
  • Michihiro Sakamoto
Article
  • 33 Downloads

Abstract

Three cases of apocrine carcinoma of the breast were investigated by light and electron microscopy. Histologically, the tumor cells were shown to have eosinophilic granular cytoplasm and occasional cytoplasmic snouts protruding into the lumen. Ultrastructurally, light and dark tumor cells were identified, and there were many lysosome-like dense bodies of various sizes and small dense granules grouped in the subapical region. Many mitochondria with incomplete cristae and numerous small vacuoles were distributed in the cytoplasm. Occasionally, intracytoplasmic lumen were visible in the tumor cells. These ultrastructural findings are quite similar to those found in normal apocrine sweat glands. However, the presence of an intraductal component of carcinoma suggests the origin to be mammary epithelial cells.

Key words

Breast cancer Apocrine carcinoma Ultrastructure 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1).
    Frable, W.J. andKay, S.: Carcinoma of the breast: histologic and clinical features of apocrine tumors.Cancer,21, 756–763 (1968).PubMedGoogle Scholar
  2. 2).
    World Health Organization: Histological typing of breast tumors.In: International Histological Classification of Tumors, 2nd ed., p. 21, WHO, Geneva, 1981.Google Scholar
  3. 3).
    Haagensen, C.D., Bodian, C. andHaagensen, D.E., Jr.: Risk and detection.In: Breast Carcinoma, p. 103–104, W.B. Saunders, Philadelphia, 1981.Google Scholar
  4. 4).
    Roddy, H.J. andSilverberg, S.G.: Ultrastructural analysis of apocrine carcinoma of the human breast.Ultrastruct. Pathol. 1, 385–393 (1980).PubMedGoogle Scholar
  5. 5).
    Paties, C., Taccagni, G.L., Papotti, M., Valente, G., Zangrandi, A. andAloi, F.: Apocrine carcinoma of the skin: a clinicopathologic, immunocytochemical, and ultrastructural study.Cancer,71, 375–381 (1993).PubMedGoogle Scholar
  6. 6).
    Pier, W.J., Garancis, J.C. andKuzma, J.F.: The ultrastructure of apocrine cells: in intracystic papilloma and fibrocystic disease of the breast.Arch. Pathol. 89, 446–452 (1970).PubMedGoogle Scholar
  7. 7).
    Archer, F. andOmar, M.: Pink cell (oncocytic) metaplasia in a fibroadenoma of the human breast: electron-microscope observations.J. Pathol. 99, 119–124 (1969).PubMedGoogle Scholar
  8. 8).
    Bonser, G.M., Dossett, J.A. andJull, J.W.: Human and Experimental Breast Cancer, p. 298, Pitman Medical, London, 1961.Google Scholar
  9. 9).
    Kurosumi, K., Shibasaki, S. andIto, T.: Cytology of secretion in mammalian sweat glands.Int. Rev. Cytol. 87, 253–329 (1984).PubMedGoogle Scholar
  10. 10).
    Kurosumi, K., Kobayashi, Y. andBaba, N.: The fine structure of mammary glands of lactating rats, with special reference to the apocrine secretion.Exp. Cell Res. 50, 177–192 (1968).CrossRefPubMedGoogle Scholar
  11. 11).
    Eusebi, V., Millis, R.M., Cattani, M.G., Bussolati, G. andAzzopardi, J.G.: Apoerine carcinoma of the breast: a morphologic and immunocytochemical study.Am. J. Pathol. 123, 532–541 (1986).PubMedGoogle Scholar
  12. 12).
    Mazoujian, G., Warhol, M.J. andHaagensen, D.E., Jr.: The ultrastructural localization of gross cystic disease fluid protein (GCDFP-15) in breast epithelium.Am. J. Pathol. 116, 305–310 (1984).PubMedGoogle Scholar
  13. 13).
    Dawson, K.E.: Sweat carcinoma of the breast.Edinb. Med. J. 39, 409 (1932).Google Scholar
  14. 14).
    Haagensen, C.D.: Apocrine epithelium.In: Disease of the Breast, p. 82–101, W.B. Saunders, Philadelphia, 1986.Google Scholar
  15. 15).
    Foote, F.W. andStewart, F.W.: Comparative studies of cancerous versus noncancerous breasts.Ann. Surg. 121, 6 (1945).Google Scholar

Copyright information

© The Clinical Electron Microscopy Society of Japan 1994

Authors and Affiliations

  • Masafumi Kurosumi
    • 1
  • Michihiro Sakamoto
    • 2
  1. 1.Department of Clinical PathologySaitama Cancer CenterSaitamaJapan
  2. 2.Division of Electron MicroscopySaitama Cancer CenterSaitamaJapan

Personalised recommendations