Abstract
A 16-year-old girl with duodenal ulcer, who had been given an H2-receptor blocker for 4 years intermittently, exhibited severe pyloric stenosis. Laboratory studies revealed she had gastric acid hypersecretion accompanied by remarkable hypergastrinemia. Samples of the antral mucosa taken preoperatively indicated gastrin cell (G cell) hyperplasia. An ultrastructural study showed a hyperfunctional state among the G cells. However, no gastrinoma was detected and her serum gastrin level fell to normal values after antrectomy with selective vagotomy. This fact led us to a diagnosis of the case as one of “pseudo-Zollinger-Ellison syndrome”. In this case, the long-term medication with the H2-receptor blocker and/or severe pyloric stenosis may have been responsible for the G cell hyperplasia and failure of physiological acid inhibition upon gastrin release.
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Osaka, M., Aizawa, K., Suzuki, T. et al. A case of duodenal ulcer with antral gastrin cell hyperplasia. Med Electron Microsc 26, 105–110 (1993). https://doi.org/10.1007/BF02348035
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DOI: https://doi.org/10.1007/BF02348035