To clarify the fine structure of esophageal dysplasia, desmosomes and nuclei were evaluated numerically and morphologically using the electron microscope. Thirteen punch biopsies were taken from patients with esophageal dysplasia ascertained by iodine staining and showing up as unstained or faintly stained areas. We conducted a morphological study of two types of esophageal dysplasia, one with reactive immature epithelium (RIE) and the other classified as an intra-epithelial neoplastic lesion (INL). The ultrastructural differences observed between the RIE and INL were the degree of the cellular or nuclear atypia, the number of desmosomes or hemidesmosomes, and the amount of intercellular space. The nucleocytoplasmic ratio in INL was higher than in RIE. In the cells of RIE, the number of desmosomes was smaller than in normal epithelium, but larger than in INL. The hemidesmosomes were found predominantly between the RIE cells and basal laminae, but were very few or absent in INL and tumor cells.
Esophageal dysplasia Desmosome Nucleocytoplasmic ratio
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