Abstract
Inflammatory cells in tubulointerstitial lesions were investigated electron microscopically in 6 cases of IgA nephritis and 4 cases of drug-induced nephropathy. Urinary beta 2 microglobulin and N-acethyl-glucosaminidase values were higher in the drug-induced nephropathy group. Both nephropathy groups had the same inflammatory cell composition in the interstitium in which T lymphocytes and macrophages were dominant. By electron microscopy these inflammatory cells were observed to infiltrate into renal tubules through the tubular basement membrane. Inflammated tubules showed various epithelial injuries. These findings suggest that inflammatory cells were actively involved in the epithelial injuries of IgA nephritis possibly through a cellular immune mechanism.
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References
Berger, J.: IgA glomerular deposits in renal disease.Transplant. Proc. 1, 939–944 (1969).
Abe, S., Amagaki, Y., Iyori, S., Konishi, K., Kato, E. andSakaguchi, H.: Significance of tubulointerstitial lesions in biopsy specimens of glomerulonephritis patients.Am. J. Nephrol. 18, 30–37 (1989).
Alexopoulos, E., Seron, D., Hartley, R.B., Nolasco, F. andCameron, J.S.: Immune mechanism in idiopathic membranous nephropathy: the role of the interstitial infiltrates.Am. J. Kidney Dis. 13, 404–412 (1989).
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Nádasdy, T., Ormos, J., Stiller, D., Csajbók, E. andSzenohradszky, E.: Tubular ultrastructure in rejected human renal allografts.Ultrastruct. Pathol. 12, 195–207 (1988).
Cameron, J.S.: Tubular and interstitial factors in the progression of glomerulonephritis.Pediatr. Nephrol. 6, 292–303 (1992).
References
Berger, J.: IgA glomerular deposits in renal disease.Transplant. Proc. 1, 939–944 (1969).
Abe, S., Amagaki, Y., Iyori, S., Konishi, K., Kato, E. andSakaguchi, H.: Significance of tubulointerstitial lesions in biopsy specimens of glomerulonephritis patients.Am. J. Nephrol. 18, 30–37 (1989).
Alexopoulos, E., Seron, D., Hartley, R.B., Nolasco, F. andCameron, J.S.: Immune mechanism in idiopathic membranous nephropathy: the role of the interstitial infiltrates.Am. J. Kidney Dis. 13, 404–412 (1989).
Olsen, T.S., Wassef, N.F., Olsen, H.S. andHansen, H.E.: Ultrastructure of the kidney in acute interstitial nephritis.Ultrastruct. Pathol. 10, 1–16 (1986).
Nádasdy, T., Ormos, J., Stiller, D., Csajbók, E. andSzenohradszky, E.: Tubular ultrastructure in rejected human renal allografts.Ultrastruct. Pathol. 12, 195–207 (1988).
Cameron, J.S.: Tubular and interstitial factors in the progression of glomerulonephritis.Pediatr. Nephrol. 6, 292–303 (1992).
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Mangkalanond, K., Ehara, T., Shigematsu, H. et al. Investigation of inflammatory cells in tubulointerstitial lesions in IgA nephritis with special reference to tubular lesions. Med Electron Microsc 26, 211–213 (1993). https://doi.org/10.1007/BF02348003
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DOI: https://doi.org/10.1007/BF02348003