Medical Electron Microscopy

, Volume 26, Issue 3–4, pp 195–198 | Cite as

Ultrastructural effects of granulocyte colony stimulating factor (G-CSF) and macrophage colony stimulating factor (M-CSF) on rat neutrophils and monocytes

  • Mitsuoki Eguchi
  • Saiki Azakami
  • Yoshihiko Iwama
  • Setsuo Sugiyama
  • Hitoshi Sakakibara
  • Kenichi Sugita
  • Keiichiro Yamaguchi
  • Toshiharu Furukawa
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Abstract

Human granulocyte colony stimulating factor (G-CSF) and macrophage colony stimulating factor (M-CSF) were administered intravenously to rats, and their effects on neutrophils and monocytes were examined by electron microscopy. G-CSF increased the number of cytoplasmic granules in neutrophils. It also enhanced maturation of the nuclear shape in the neutrophils, while chromatin condensation and peroxidase distribution remained immature. M-CSF induced proliferation of monocytes in peripheral blood and bone marrow, but did not affect morphology or distribution of peroxidase reactivity.

Key words

Granulocyte colony stimulating factor (G-CSF) Macrophage colony stimulating factor (M-CSF) Neutrophil Monocyte Peroxidase 

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References

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Copyright information

© The Clinical Electron Microscopy Society of Japan 1993

Authors and Affiliations

  • Mitsuoki Eguchi
    • 1
  • Saiki Azakami
    • 1
  • Yoshihiko Iwama
    • 1
  • Setsuo Sugiyama
    • 1
  • Hitoshi Sakakibara
    • 1
  • Kenichi Sugita
    • 1
  • Keiichiro Yamaguchi
    • 2
  • Toshiharu Furukawa
    • 1
  1. 1.The Second Department of PediatricsDokkyo University School of MedicineTochigiJapan
  2. 2.Laboratory of Medical ScienceDokkyo University School of MedicineTochigiJapan

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