Calcium ions and morphological changes in the arterial wall after subarachnoid hemorrhage, with special reference to human subjects
- 8 Downloads
In order to clarify the relationship between calcium mobilization and morphological changes in the arterial wall after subarachnoid hemorrhage, electron microscopic histochemical assessments of the intracellular calcium in the arterial wall of human subjects showing vasospasm angiographically were conducted. Intracellular calcium ions in the arterial wall after subarachnoid hemorrhage were significantly more numerous than those of the control specimens. However, reaction products of calcium ions in the arterial wall were distributed mainly in the areas which morphologically revealed spastic changes such as myonecrosis and vacuoles, and there were no or extremely few reaction products of calcium ions in the areas showing no morphological changes in the arterial wall. These findings were consistent with the data for a feline model with experimental subarachnoid hemorrhage previously studied by the authors and indicated that increased intracellular calcium mobilization detected histochemically might be related to the morphological changes in the arterial wall after subarachnoid hemorrhage.
Key wordsSubarachnoid hemorrhage Calcium Cerebral vasospasm Electron microscopy
Unable to display preview. Download preview PDF.
- 4).Sasaki, T., Ohue, S., Kohno, K. andTakeda, S.: Impairment of vascular reactivity and changes in intracellular calcium and calmodulin levels of smooth muscle cells in canine basilar arteries after subarachnoid hemorrhage.Neurosurgery,25, 753–761 (1989).Google Scholar
- 5).Takagi, T., Fukuoka, H., Nagai, H. andHotta, K.: Basic on cerebral vasospasm: Ca movement during contraction-relaxation of isolated basilar arteries.Neurol. Med. Chir. (Tokyo),19, 45–52 (1979).Google Scholar
- 6).Umezawa, T., Nakamura, S., Yoshida, K., Nakano, M. andWatanabe, H.: Changes of calcium ion in the arterial wall after subarachnoid hemorrhage—an electron microscopic histochemical study.J. Clin. Electron Microsc. 23, 293–294 (1990).Google Scholar
- 7).Bogers, M., DeBrabander, M. van Reempts, J., Awouters, F. andJacob, W.A.: Intranuclear microtubules in lung mast cells of guinea pigs in anaphylactic shock.Lab. Invest. 37, 1–8 (1977).Google Scholar
- 8).White, R.P.: Vasospasm I. Experimental findings.In: Intracranial Aneurysms (Fox, J.L. ed.), p. 218–249, Springer, New York, 1983.Google Scholar
- 10).Aller, L.M..: Acute operation and preventive nimodipine improve outcome in patients with ruptured cerebral aneurysms.Neurosurgery,15, 57–66 (1984).Google Scholar