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Medical Electron Microscopy

, Volume 28, Issue 1, pp 33–37 | Cite as

Calcium ions and morphological changes in the arterial wall after subarachnoid hemorrhage, with special reference to human subjects

  • Kenshi Yoshida
  • Hiroshi Watanabe
  • Saburo Nakamura
  • Masahito Nakano
  • Yuichi Ueno
  • Yuji Koike
  • Takashi Tsubokawa
Article

Abstract

In order to clarify the relationship between calcium mobilization and morphological changes in the arterial wall after subarachnoid hemorrhage, electron microscopic histochemical assessments of the intracellular calcium in the arterial wall of human subjects showing vasospasm angiographically were conducted. Intracellular calcium ions in the arterial wall after subarachnoid hemorrhage were significantly more numerous than those of the control specimens. However, reaction products of calcium ions in the arterial wall were distributed mainly in the areas which morphologically revealed spastic changes such as myonecrosis and vacuoles, and there were no or extremely few reaction products of calcium ions in the areas showing no morphological changes in the arterial wall. These findings were consistent with the data for a feline model with experimental subarachnoid hemorrhage previously studied by the authors and indicated that increased intracellular calcium mobilization detected histochemically might be related to the morphological changes in the arterial wall after subarachnoid hemorrhage.

Key words

Subarachnoid hemorrhage Calcium Cerebral vasospasm Electron microscopy 

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Copyright information

© The Clinical Electron Microscopy Society of Japan 1995

Authors and Affiliations

  • Kenshi Yoshida
    • 1
  • Hiroshi Watanabe
    • 1
  • Saburo Nakamura
    • 1
  • Masahito Nakano
    • 1
  • Yuichi Ueno
    • 2
  • Yuji Koike
    • 2
  • Takashi Tsubokawa
    • 1
  1. 1.Department of Neurological SurgeryNihon University School of MedicineTokyoJapan
  2. 2.Yokosuka Municipal HospitalYokosukaJapan

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