Abstract
A case of central neurocytoma was studied by electron microscopic and immunohistochemical methods. Immunohistochemical examinations showed the tumor cells to be positive for neuron-specific enolase, sporadically positive for synaptophysin, and negative for glial fibrillary acidic protein. The Ki-67 (MIB-1) positive index value for the tumor cells was a low 1.5%. Ultrastructurally, thin cytoplasmic processes of tumor cells showed differentiation to neuronal cells containing parallel bundles of microtubules and abortive synapses with dense core vesicles and/or clear vesicles. Microvessels composed of endothelial cells without fenestrations and tight junctions in the endothelial clefts appeared in fibrillary stromas as revealed by light microscopy. Neurosecretory granules in thin cell processes may have been secreted around microvessels.
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Hassoun, J., Gambarelli, D., Grisoli, F., Pellet, W., Salamon, G., Pellissier, J.F. andToga, M.: Central neurocytoma; an electron microscopic study of two cases.Acta Neuropathol. (Berl.) 56, 151–156 (1982).
Townsend, J.J. andSeaman, J.P.: Central neurocytoma—a rare benign intraventricular tumor.Acta Neuropathol. (Berl.) 71, 167–170 (1986).
Nishio, S., Tashima, T., Takeshita, I. andFukui, M.: Intraventricular neurocytoma; clinicopathological features of six cases.J. Neurosurg. 68, 665–670 (1988).
Tsujita, Y., Nagashima, K. andTakakura, K.: A clinico-pathological study of central neurocytoma.No to Shinkei,41, 547–558 (1989).
Miyata, K., Yamashita, H., Shirakata, S. andTakeda, Y.: A case of central neurocytoma.Neurol. Med. (Tokyo) 29, 1148–1152 (1989).
Barbosa, M.D., Balsitis, M., Jaspan, T. andLowe, J.: Intraventricular neurocytoma; a clinical and pathological study of three cases and review of the literature.Neurosurgery,26, 1045–1054 (1990).
Louis, D.N., Swearingen, B., Linggood, R.M., Dickersin, G.R., Kretchmer, C., Bahn, A.K. andHedley-Whyte, T.: Central nervous system neurocytoma and neuroblastoma in adults—report of eight cases.J. Neurooncol. 9, 231–238 (1990).
Okada, T., Fukao, S., Nakasu, Y. andHanda, J.: Central neurocytoma; report of a case.Arch. Jpn. Chir. 59, 330–336 (1990).
Patil, A.A., McComb, R.D., Gelber, B., McConnell, J. andSasse, S.: Intraventricular neurocytoma; a report of two cases.Neurosurgery,1, 140–144 (1990).
Tamiya, T., Furuta, T., Asari, S. andNishimoto, A.: Central neurocytoma; case report.Neurol. Med. Chir. (Tokyo) 30, 178–183 (1990).
Casadei, G.P., Arrigoni, G.L., Versari, P., Gambacorta, M. andGiangaspero, F.: Central neurocytoma; a clinico-pathologic study of five cases.Tumori,77, 323–327 (1991).
Kubota, T., Hayashi, M., Kawano, H., Kabuto, M., Sato, K., Ishise, J., Kawamoto, K., Shirataki, K., Iizuka, H., Tsunoda, S. andKatsuyama, J.: Central neurocytoma; immunohistochemical and ultrastructural study.Acta Neuropathol. 81, 418–427 (1991).
Figarella-Branger, D., Pellissier, J.F., Daumas-Duport, C., Delisle, M.B., Pasquier, B., Parent, M., Gambarelli, D., Rougon, G. andHassoun, J.: Central neurocytomas. Critical evaluation of a small-cell neuronal tumor.Am. J. Surg. Pathol. 16, 97–109 (1992).
Hessler, R.B., Lopes, M.B.S., Frankfurter, A., Redy, J. andVandenberg, S.R.: Cytoskeletal immunohistochemistry of central neurocytoma.Am. J. Surg. Pathol. 16, 1031–1038 (1992).
Kim, D.G., Chi, J.G., Park, S.H., Chang, K.H., Lee, S.H., Jung, H.W., Kim, H.J., Cho, B.K., Choi, K.S. andHan, D.H.: Intraventricular neurocytoma; clinicopathological analysis of seven cases.J. Neurosurg. 76, 759–765 (1992).
Yasargil, M.G., von Ammon, K., von Deimling, A., Valavanis, A., Wichmann, W. andWiestler, O.D.: Central neurocytoma; histopathological variants and therapeutic approaches.J. Neurosurg. 76, 32–37 (1992).
Tatter, S.B., Borges, L.F. andLouis, D.N.: Central neurocytomas of cervical cord. Report of two cases.J. Neurosurg. 81, 288–293 (1994).
Dranoff, G. andBigner, D.D.: A word of caution in the use of neuron specific enolase expression in tumor diagnosis.Arch. Pathol. Lab. Med. 108, 535 (1984).
Wiedenmann, B. andFranke, W.W.: Identification and localization of synaptophysin an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles.Cell,41, 1017–1028 (1985).
Gould, V.E., Wiedenmann, B., Lee, I., Schwechheimer, K., Dockhorn-Dworniczak, B., Radosevich, J.A., Moll, R. andFranke, W.W.: Synaptophysin expression in neuroendocrine neoplasms as determined by immunocytochemistry.Am. J. Pathol. 126, 243–257 (1987).
Von Deimling, A., Janzer, R., Kleihues, P. andWiestler, O.D.: Patterns of differentiation in central neurocytoma. A immunohistochemical study of eleven biopsies.Acta Neuropathol. 79, 473–479 (1990).
Burger, P.C., Shibata, T. andKleihaus, P.: The use of monoclonal antibody Ki 67 in the identification of proliferating cells.Am. J. Surg. Pathol. 10, 611–617 (1986).
Zuber, P., Hamou, M.F. andde Tribolet, N.: Identification of proliferating cells in human gliomas using the monoclonal antibody Ki 67.Neurosurgery,22, 364–368 (1988).
Torres, L.F., Grant, N., Harding, B.N., andScaravilli, F.: Intracerebral neuroblastoma. Report of a case with neuromaturation and long survival.Acta Neuropathol. (Berl.) 68, 110–114 (1985).
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Miyagami, M., Miyagi, A. & Tsubokawa, T. An ultrastructural and immunohistochemical study of central neurocytoma. Med Electron Microsc 28, 163–171 (1995). https://doi.org/10.1007/BF02347959
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DOI: https://doi.org/10.1007/BF02347959