Abstract
A 47-year-old man with primary amyloidosis was admitted with abdominal pain. A new radionuclide liver imaging technique using Technetium-99 m diethylenetriamine-pentaacetic acid-galactosyl human serum albumin, was performed and the serum hyaluronate concentration was measured. Although ordinary laboratory tests revealed only slight abnormalities, the uptake of the radiolabelled ligand for hepatocyte asialo-glycoprotein receptors was dereased, and marked hepatomegaly was revealed. Furthermore, the serum hyaluronate level was elevated. Histological examination of a hepatic needle biopsy specimen revealed a marked deposition of amyloid in the hepatic perisinusoidal spaces. These results indicate, that this new radionuclide liver imaging technique (using Technetium-99 m diethylenetriamine-pentaacetic acid-galactosyl human serum albumin) and the measurement of serum hyaluronate may be useful supplementary tools for identifying amyloid deposition in the hepatic perisinusoidal spaces in patients with amyloidosis.
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Hashimoto, O., Harada, M., Sata, M. et al. Functional liver imaging with asialoglycoprotein receptors and serum hyaluronate in a patient with amyloidosis. J Gastroenterol 30, 403–407 (1995). https://doi.org/10.1007/BF02347519
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DOI: https://doi.org/10.1007/BF02347519