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Interferon treatment of chronic hepatitis C in patients with hemophilia or von Willebrand's disease in Japan

  • Liver, Pancreas, and Biliary Tract
  • Published:
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Abstract

Seven patients with chronic hepatitis C, six hemophiliacs and a patient with von Willebrand's disease, were treated with interferon-alpha (IFN-alpha). Either 9 MU of recombinant IFN-alpha 2a or 3 MU of lymphoblastoid alpha-IFN was administered daily for 2 weeks and then three times a week for 22 weeks. Liver histology, hepatitis C virus (HCV) genotypes, and HCV-RNA levels in sera were investigated in all of the patients before IFN therapy was instituted. Liver histology was classified by the European classification. HCV genotyping conformed to the so-called Okamoto's classification. HCV-RNA levels in sera were quantitated by competitive polymerase chain reaction, using mutant RNA. Liver histology, HCV genotype, and serum HCV-RNA level (copies/ml) in each patient were: patient 1, chronic persistent hepatitis, type II, 3×103 respectively; patient 2, chronic active hepatitis (CAH) 2a, type III, 6×104; patient 3, CAH2a, type IV, 2×105; patient 4, CAH2b, type I, 2×107; patient 5, CAH2b, type II, 8×104; patient 6, CAH2b, type III, 7×106; and patient 7, CAH2b, type IV, 1×107. Sustained elimination of HCV was achieved in patient 3 and temporary elimination was achieved in patients 1 and 2. The other patients showed persistent HCV-RNA positivity in sera both during and after IFN treatment. Poor responsiveness to IFN was observed in patients with relatively progressive liver histology and high levels of HCV viremia.

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Authors and Affiliations

  1. The Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, 634, Kashihara, Nara, Japan

    Masahide Yoshikawa, Hiroshi Fukui, Hideyuki Kojima, Hitoshi Yoshiji, Takemi Sakamoto, Hiroo Imazu, Toshiya Nakanani, Yoshinobu Matsumura, Junichi Yamao, Masato Uemura, Akira Takaya & Tadasu Tsujii

  2. Department of Pediatrics, Nara Medical University, 840 Shijo-cho, 634, Kashihara, Nara, Japan

    Shigeki Kuriyama, Midori Shima & Akira Yoshioka

Authors
  1. Masahide Yoshikawa
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  2. Hiroshi Fukui
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  3. Hideyuki Kojima
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  4. Hitoshi Yoshiji
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  5. Takemi Sakamoto
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  6. Hiroo Imazu
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  7. Toshiya Nakanani
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  8. Yoshinobu Matsumura
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  9. Shigeki Kuriyama
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  10. Junichi Yamao
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  11. Masato Uemura
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  12. Akira Takaya
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  13. Tadasu Tsujii
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  14. Midori Shima
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  15. Akira Yoshioka
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Yoshikawa, M., Fukui, H., Kojima, H. et al. Interferon treatment of chronic hepatitis C in patients with hemophilia or von Willebrand's disease in Japan. J Gastroenterol 30, 367–371 (1995). https://doi.org/10.1007/BF02347513

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  • DOI: https://doi.org/10.1007/BF02347513

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