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In vitro and in vivo studies of99mTc IgG: A comparison between three labeling methods

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Abstract

Polyclonal immunoglobulin IgG was labeled using three different methods: a direct method via 2-mercaptoethanol, an indirect one, in which a chelating group was covalently attached to the protein and the99mTc added as a glucoheptonate complex and a photoactivation method. The properties of99mTc polyclonal antibody labeled by three different methods were assessed by in vitro and in vivo studies. The ratio between inflamed thigh to normal thigh was similar and independent of the method of labeling.

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Authors and Affiliations

  1. Comisión Nacional de Energía Atómica, Centro Atómico Ezeiza, Av. Libertador 8250, 1419, Buenos Aires, Argentina

    M. E. Viaggi, J. Crudo & S. G. de Castiglia

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  1. M. E. Viaggi
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  2. J. Crudo
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  3. S. G. de Castiglia
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Viaggi, M.E., Crudo, J. & de Castiglia, S.G. In vitro and in vivo studies of99mTc IgG: A comparison between three labeling methods. J Radioanal Nucl Chem 241, 173–177 (1999). https://doi.org/10.1007/BF02347306

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  • DOI: https://doi.org/10.1007/BF02347306

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