Pflügers Archiv

, Volume 431, Supplement 6, pp R223–R224 | Cite as

Histaminergic drugs as modulators of CNS function

  • Gillian Sturman
Article

Abstract

The first indication that histamine might be important in the functioning of the brain was the finding that the centrally penetrating histamine H1 antagonists had marked sedative properties. Subsequently with the development of more specific compounds and drugs for the H1, H2 and H3 receptors a greater understanding of the neurotransmitter/modulator role of histamine in the CNS has been possible. Histamine is now associated with wakefulness, suppression of seizures, hypothermia and emesis. The histamine H1 antagonists have been shown to potentiate opioid-induced analgesia, and modify eating and drinking patterns as well as endocrine secretions from the pituitary gland. Additionally, clinically useful antidepressants have been shown to inhibit histamine-sensitive adenylate cyclase from the mammalian brain. Recently, a possible role for both histamine H1 and H2 receptors in schizophrenia has been reported. As more specific and centrally-penetrating histaminergic compounds are developed, so the roles of histamine as a neurotransmitter/modulator in the brain will be better understood.

Key words

Histamine Neurotransmitter Neuromodulator CNS Review 

References

  1. 1.
    Arrang, J-M., Garbarg, M. & Schwartz, J-C. (1985) Autoregulation of histamine release in brain by presynaptic H3 receptors. Neuroscience, 15, 553–562CrossRefPubMedGoogle Scholar
  2. 2.
    Freeman, P. & Sturman, G. (1989) Potentiation of morphine-induced antinociception in mice by centrally- but not peripherally-acting histamine H1 antagonists. Br.J. Pharmacol., 97, 486PGoogle Scholar
  3. 3.
    Fukui, H. (1991) Histamine receptors: H1- and H2-receptors. In: Histaminergic Neurons: Morphology and Function. Ed. Watanabe, T. & Wada, H.CRC Press. pp 61–83.Google Scholar
  4. 4.
    Matsulaga,T. & Takeda, N. (1991) Motion Sickness. In: Histaminergic Neurones: Morphology and Function. Ed. Watanabe,T. & Wada, H. CRC Press. pp 315–322Google Scholar
  5. 5.
    Prell, G.D., Green, J.P., Kaufmann, C.A., Khandelwal, J.K., Morrishow, A.M., Kirch, D.G., Linnoila, M. & Wyatt, R.J. (1995) Histamine metabolites in cerebrospinal fluid of patients with chronic schizophrenia: their relationships to levels of other aminergic transmitters and rating of symptoms. Schizophrenic Res. 14, 93–104Google Scholar
  6. 6.
    Schwartz, J-C., Garbarg, M. & Quach, T.T. (1981) Histamine receptors in brain as targets for tricyclic antidepressants. T.I.P.S., 2, 122–125Google Scholar
  7. 7.
    Sturman, G. & Freeman, P. (1992) Histaminergic modulation and chemically-induced seizures. Agents Actions, 36, C358-C360CrossRefGoogle Scholar
  8. 8.
    Sturman, G., Freeman,P., Jakobson, M.E., John, T.H. & Nicol, S. (1991) Effects of histaminergic modulation on the body temperature in mice. Br.J. Pharmacol., 104,270PGoogle Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Gillian Sturman
    • 1
  1. 1.Department of Life SciencesUniversity of East LondonLondonUK

Personalised recommendations