Diabetologia

, Volume 7, Issue 1, pp 1–5 | Cite as

The role of the exocrine pancreas in the stimulation of insulin secretion by intestinal hormones

I. The effect of pancreozymin, secretin, gastrin-pentapeptide and of glucagon upon insulin secretion of isolated islets of rat pancreas
  • M. Hinz
  • N. Katsilambros
  • B. Schweitzer
  • S. Raptis
  • E. F. Pfeiffer
Originals

Summary

The effect of the intestinal hormones secretin, pancreozymin, gastrin-pentapeptide and of glucagon upon insulin secretion of rat isolated pancreatic islets were studied. Only pancreozymin and glucagon were found to stimulate insulin release from the isolated islets, pancreozymin without and glucagon only in presence of glucose in the medium. The effect of pancreozymin was repeatedly shown by using the same islets in a dynamic perifusion system. The studies imply classification of the insulin stimulating actions of the intestinal hormones according to dependence upon and independence of the presence of intact exocrine pancreatic tissue.

Key-words

Intestinal hormones isolated pancreatic islets insulin release 

Le rôle du pancréas exocrine dans la stimulation de la sécrétion de l'insuline par des hormones intestinales

I. L'effet de la pancréozymine, de la sécrétine, du gastrinepentapeptide et du glucagon sur la sécrétion d'insuline des îlots pancréatiques isolés du rat

Résumé

L'effet des hormones intestinales sécrétine, pancréozymine, gastrine-pentapeptide et glucagon sur la sécrétion d'insuline des ilôts pancréatiques isolés du rat a été étudié. Seule la pancréozymine et le glucagon se sont avérés stimuler la sécrétion d'insuline des ilôts isolés. La pancréozymine a produit cet effet sans glucose et le glucagon ne l'a produit qu'en présence de glucose dans le milieu. L'effet de la pancréozymine a été montré à plusieurs reprises en utilisant les même ilôts dans un système de perifusion dynamique. Ces études impliquent une classification des hormones intestinales, qui stimulent la sécrétion d'insuline selon que le tissu pancréatique exocrine intact est présent ou non.

Die Rolle des exocrinen Pankreas bei der Stimulierung der Insulinsekretion durch intestinale Hormone

I. Die Wirkung von Pankreozymin, Secretin, Gastrin-Pentapeptid und Glucagon auf die Insulinsekretion isolierter Pankreasinseln der Ratte

Zusammenfassung

Der Effekt der intestinalen Hormone Secretin, Pankreozymin, Gastrin-Pentapeptid und Glucagon auf die Insulinsekretion isolierter Langerhans'scher Inseln der Ratte wurde untersucht. Nur Pankreozymin und Glucagon stimulierten die Insulinsekretion der isolierten Inseln, Pankreocymin ohne, Glucagon nur bei Zusatz von Glucose zum Medium. Dieser Effekt von Pankreozymin war wiederholt an denselben Inseln in einem dynamischen Perifusionssystem nachzuweisen. Die Untersuchungen zeigen, daß die insulinstimulierende Wirkung der intestinalen Hormone zum Teil an ein funktionsfähiges exocrines Pankreasgewebe gebunden ist, zum Teil davon unabhängig zustande kommt.

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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • M. Hinz
    • 1
  • N. Katsilambros
    • 1
  • B. Schweitzer
    • 1
  • S. Raptis
    • 1
  • E. F. Pfeiffer
    • 1
  1. 1.Department of Endocrinology and Metabolism, Center of Internal Medicine and PediatricsUniversity of UlmGermany

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