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Ethylene dicysteine (EC) and ethyl cysteinate dimer (ECD) complexes of Ga(III) and In(III)

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Abstract

Ethylene dicysteine (EC) and ethyl cysteinate dimer (ECD) complexes of67Ga and111In were prepared and the complexation yield and radiochemical purity estimated by paper chromatography, paper electrophoresis and solvent extraction into chloroform.111In-EC was found to be anionic, whereas111In-ECD was neutral. EC complexes of67Ga and111In were stable upto 6 hours and expectedly less lipophilic than ECD complexes. ECD complexes of67Ga and111In were unstable in aqueous medium, but highly stable in chloroform. The utility of the work for stabilisation of products as organic extract and the possible role and limitation for the development of new68Ga radiopharmaceuticals and of bifunctional chelating agent (BCA) for111In are discussed.

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Authors and Affiliations

  1. Radiopharmaceuticals Laboratory of BRIT, Variable Energy Cyclotron Centre, 1/AF Bidhan Nagar, 700 064, Calcutta, India

    Sankha Chattopadhyay, M. K. Das & B. R. Sarkar

  2. Board of Radiation and Isotope Technology (BRIT), Project House, V. N. Purav Marg, 400 094, Mumbai, India

    N. Ramamoorthy

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  1. Sankha Chattopadhyay
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  2. M. K. Das
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  3. B. R. Sarkar
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  4. N. Ramamoorthy
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Chattopadhyay, S., Das, M.K., Sarkar, B.R. et al. Ethylene dicysteine (EC) and ethyl cysteinate dimer (ECD) complexes of Ga(III) and In(III). J Radioanal Nucl Chem 242, 29–32 (1999). https://doi.org/10.1007/BF02345891

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  • DOI: https://doi.org/10.1007/BF02345891

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