Skip to main content
Log in

Penetration of radionuclides across the skin: Concentration dependence of60Co permeation

  • Short Communication
  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

Co2+ ion penetration at different concentrations across animal models of human skin-five days old rat skin (without hairs) and nine days old rat skin (with hairs)—was studied in vitro in vertical diffusion cells. The results showed that the permeated amounts of Co2+ ions are proportional to its concentration in donor solutions, whereby permeated fractions are higher at lower concentrations. Results confirmed that the most important barrier against the penetration of ions is horny layer of the skin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. J. Severa, J. Bár, Kontaminace radioaktivními látkami a dekontaminace, CKAE, ÚIS JP, Zbaslav, 1985.

    Google Scholar 

  2. T. J. Franz, J. Invest. Dermatol., 64 (1975) 190.

    Article  CAS  Google Scholar 

  3. R. H. Guy, N. Higo, A. Naik et al. in: Prediction of Percutaneous Penetration, Vol. 2,R. C. Scott, R. H. Guy, J. Hadgraft, H. E. Boddé, (Eds) IBC Technical Services Ltd., London, 1991, p. 1.

    Google Scholar 

  4. J. Wepierre, O. Ducet, J-P. Marty, Percutaneous absorption of drugs in vitro: role of transepidermal and transfollicular routes, in: Prediction of Percutaneous Penetration,R. C. Scott, R. H. Guy, J. Hadgraft (Eds), IBC Technical Services Ltd., London, 1990, p. 129.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kassai, Z., Koprda, V. & Harangozó, M. Penetration of radionuclides across the skin: Concentration dependence of60Co permeation. J Radioanal Nucl Chem 242, 561–563 (1999). https://doi.org/10.1007/BF02345594

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02345594

Keywords

Navigation