Journal of Radioanalytical and Nuclear Chemistry

, Volume 242, Issue 2, pp 309–312 | Cite as

[11C]-labeling of some caffeine derivatives for mapping adenosine A2a receptors by PET technique

  • I. Boros
  • G. Horváth
  • S. Lehel
  • T. Márián
  • Z. Kovács
  • J. Szentmiklósi
  • G. Tóth
  • L. Trón
Article

Abstract

[11C]-labeled form of ten A2a adenosine receptor specific 8-styryl-7-methyl-xanthine derivatives ([11C]-caffeines) were synthesised by N-methylation of the corresponding 8-styryl-xanthine derivatives using [11C]-methyl iodide in optimized reaction conditions. The results show that the [11C]-methylations take place with excellent radiochemical yields (35–93%), and can be utilised easily in online preparations. These labeled ligands may facilitate the positron emission tomographic (PET) investigation of adenosine A2a receptors.

Keywords

Methyl Inorganic Chemistry Adenosine Iodide Caffeine 

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Copyright information

© Akadémiai Kiadó 1999

Authors and Affiliations

  • I. Boros
    • 1
  • G. Horváth
    • 1
  • S. Lehel
    • 1
  • T. Márián
    • 1
  • Z. Kovács
    • 2
  • J. Szentmiklósi
    • 3
  • G. Tóth
    • 4
  • L. Trón
    • 1
  1. 1.PET CentreUniversity Medical School of DebrecenDebrecenHungary
  2. 2.Department of PharmacologyUniversity Medical School of DebrecenDebrecenHungary
  3. 3.Institute of Nuclear Research of the Hungarian Academy of ScienceDebrecenHungary
  4. 4.Institute of Isotopes Co. Ltd.BudapestHungary

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