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Transient phase locking patterns among respiration, heart rate and blood pressure during cardiorespiratory synchronisation in humans

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Abstract

The interactions between respiration, heart rate and blood pressure variability (HRV, BPV), are considered to be of paramount importance for the study of the functional organisation of the autonomic nervous system (ANS). The aim of the reported study is to detect and classify the intermittent phase locking (PL) phenomena between respiration, HRV and BPV during cardiorespiratory synchronisation experiments, by using the following time-domain techniques: Poincaré maps, recurrence plots, time-space separation plots and frequency tracking locus. The experimental protocol consists of three stages, with normal subjects in paced breathing at 15, 12 and 8 breaths min−1. Transient phenomena of coordination between respiration and the major rhythms of HRV and BPV (low and high frequency, LF and HF) have been detected and classified: no interaction between LF and HF rhythms at 15 breaths min−1; short time intervals of stable 1∶2 frequency and phase synchronisation during the 12 breaths min−1 stage; 1∶1 PL during the 8 breaths min−1 stage. 1∶1 and 1∶2 PL phenomena occurred when the respiration frequency was quite close to the LF frequency or when it was about twice the LF frequency, respectively. The complex organisation of the ANS seems to provoke transient rather than permanent PL phenomena between the co-ordinating components of respiration and cardiovascular variability series.

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References

  • Akselrod, S. (1981): ‘Spectrum analysis of hearth rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control’,Science,213, pp. 220–222

    Google Scholar 

  • De Burgh, andDaly, M. (1995): ‘Aspects of the integration of the respiratory and cardiovascular systems’, in Jordan D. and Marshall J. (Eds), ‘Cardiovascular regulation’ (Portland Press), Chapter 2

  • Eckmann, J. P., Kamphorst, S. O. andRuelle, D. (1987): ‘Recurrence plots of dynamical systems’,Europhys Lett.,4, pp. 973–977

    Google Scholar 

  • Glass, L. (1991): ‘Cardiac arrhytmias and circle maps—a classical problems’,Chaos,1, pp. 13–19

    MATH  MathSciNet  Google Scholar 

  • Guevara, M. R., Glass, L. andShrier, A. (1981): ‘Phase locking, Period-Doubling biforcations, and irregular dynamics in periodically stimulated cardiac cells’,Science,214, pp. 1350–1352

    Google Scholar 

  • Hayashi, C. (1964): ‘Non-linear oscillations in physical systems’ (McGraw Hill, New York)

    Google Scholar 

  • Hoyer, D., Bauer, R., Walter, B. andZwiener, U. (1998a): ‘Estimation of non-linear couplings on the basis of complexity and predictability—a new method applied to cardiorespiratory coordination’,IEEE Trans.,BME 45, pp. 1–8

    Google Scholar 

  • Hoyer, D., Hader, O. andZwiener, U. (1997): ‘Relative and intermittent cardiorespiratory coordination’,IEEE Eng. Med. Biol.,16, pp. 97–104

    Google Scholar 

  • Hoyer, D., Kaplan, D., Palus, M., Pompe, B. andSeidel, H. (1998b): ‘New systems-analytical approaches to nonlinear coordination’,IEEE Eng. Med. Biol.,17, pp. 58–61

    Google Scholar 

  • Hoyer, D., Kaplan, D., Schaaff, F. andElselt, M. (1998c): ‘Determinism in bivariate cardioresporatory phase-space sets’,IEEE Eng. Med. Biol.,17, pp. 26–31

    Google Scholar 

  • Hoyer, D., Pompe, B., Herzel, H. andZwiener, U. (1998d): ‘Non-linear coordination of cardiovascular autonomic control’,IEEE Eng. Med. Biol.,17, pp. 17–21

    Google Scholar 

  • Hoyer, D., Schmidt, K., Zwiener, U. andBauer, R. (1996): ‘Characterization of complex heart rate dynamics and their pharmacological disorders by non-linear prediction and special data transformation’,Cardiovasc. Res.,31, pp. 434–440

    Article  Google Scholar 

  • Hyndman, B. W., Kitney, R. I. andSayers, B. M. (1971): ‘Spontaneous rhythms in physiological control systems’,Nature,233, pp. 339–341

    Article  Google Scholar 

  • Kitney, R. I. (1985): ‘Beat-by-beat interrelationships between heart rate, blood pressure, and respiration, in Kitney, R. I. and Rompelman, O. (Eds), The beat-by-beat investigation of cardiovascular function’ (Calderon Press), pp 146–178

  • Kitney, R. I. andBignall, S. (1990): ‘Techniques for studying shortterm changes in heart rate variability’. Proc. 5th European meeting on hypertension. Computer analysis of the blood pressure signal research and clinical applications, Mancia, G. Pedotti, A. and Zanchetti, A. (Eds), pp 50–79

  • Kitney, R. I., Linkens, D., Sekman, A. andMcDonald, A. (1982): ‘The interaction between heart rate and respiration: part II-non-linear analysis based on computer modeling’,Automedica,4, pp. 141–153

    Google Scholar 

  • Kitney, R. I. andSeydnejad, S. R. (1998): ‘The nonlinear closed loop mechanism underlying the LF oscillation in blood pressure’ Proc. 20th IEEE Ann. Int. Conf. Engineering in Medicine and Biology, pp. 271–274

  • Kurths, J., Voss, A., Saparin, P., Witt, A., Kleiner, H. J. andWessel, N. (1995): ‘Quantitative analysis of heart rate variability’,Chaos,5, pp. 88–94

    Article  Google Scholar 

  • Mackey, M. C. andGlass, L. (1977): ‘Oscillation and choas in physiological control systems’,Science,197, pp. 287–289

    Google Scholar 

  • Malliani, A., Pagani, M., Lombardi, F. andCerutti, S. (1991): ‘Cardiovascular neural regulation explored in the frequency domain’,Circulation,84, pp. 482–492

    Google Scholar 

  • Miyakawa, K., Koepchen, H. P. andPolosa, C. (1984): ‘Mechanisms of blood pressure waves’ (Springer Verlag, New York)

    Google Scholar 

  • Novak, V., Novak, P., Da Champlain, J., Le Blanc, A. R., Martin, R. andNadeau, R. (1993): ‘Influence of respiration on heart rate and blood pressure fluctuations’,J. Appl. Physiol.,74, pp. 617–626

    Google Scholar 

  • Pagani, M., Lombardi, F., Guzetti, S., Rimidli, O., Furlan, R., Pizzinelli, P., Sandrone, G., Maleatto, G., Dell'Orto, S., Piccaluga, E., Turiel, M., Baselli, G., Cerutti, S. andMalliani, A. (1986): ‘Power spectral analysis of a beat-to-beat heart rate and blood pressure variability as a possible marker of symphato-vagal interaction in man and conscious dog’,Circ. Res.,59, pp. 178–193

    Google Scholar 

  • Palus, M. andHoyer, D. (1998): ‘Detecting non-linearity and phase synchronization with surrogate data’,IEEE Eng. Med. Biol.,17, pp. 40–45

    Google Scholar 

  • Pompe, B., Blindh, P., Hoyer, D. andEiselt, M. (1998): ‘Using mutual information to measure coupling in the cardiorespiratory system’,IEEE Eng. Med. Biol.,17, pp. 32–39

    Google Scholar 

  • Porta, A., Baselli, G., Montano, N., Gnecchi-Ruscone, T., Lombardi, F., Malliani, A. andCerutti, S. (1996): ‘Classification of coupling patterns among spontaneous rhythms and ventilation in the sympathetic discharge of decerebrated cats’,Biol. Cybern.,75, pp. 163–172

    Article  Google Scholar 

  • Provenzale, A., Smith, L. A., Vio, R. andMurante, G. (1992): ‘Distinguishing between low-dimensional dynamics and randomness in measured time series’,Physica D,58, pp. 31–49

    Article  Google Scholar 

  • Roach, D., Malik, P., Koshman, M. L. andSheldon, R. (1999): ‘Origins of heart rate variability: inducibility and prevalence of a discrete, tachycardic event’,Circulation,99, pp. 3279–3285

    Google Scholar 

  • Rosenblum, M. G., Kurths, J., Pikovsky, A., Schafer, C., Tass, P. andAbel, H. (1998): ‘Synchronization in noisy systems and cardiorespiratory interaction’,IEEE Eng. Med. Biol.,17, pp. 46–53

    Google Scholar 

  • Seidel, H. andHerzel, H. (1998): ‘Analyzing entrainment of heart-beat and respiration with surrogates’,IEEE Eng. Med. Biol.,17, pp. 54–57

    Google Scholar 

  • Seydnejad, S. (1998): ‘Analysis of heart rate variability and blood pressure variation by nonlinear modelling techniques. PhD Thesis. Imperial College of Science, Technology and Medicine

  • Zwiener, U., Hoyer, D., Bauer, R., Luethke, B., Walter, B., Schmidt, K., Hallmeyer, S., Kratzsch, B. andEiselt, M. (1996): ‘Deterministic-chaotic and periodic properties of heart rate and arterial blood pressure fluctuations and their mediations in piglets’,Cardiovasc. Res.,31, pp. 455–456

    Article  Google Scholar 

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Censi, F., Calcagnini, G., Lino, S. et al. Transient phase locking patterns among respiration, heart rate and blood pressure during cardiorespiratory synchronisation in humans. Med. Biol. Eng. Comput. 38, 416–426 (2000). https://doi.org/10.1007/BF02345011

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