European Radiology

, Volume 5, Supplement 2, pp S54–S57 | Cite as

Iotrolan in head and body CT — European experience

  • O. Schubiger
  • M. Friedrich
  • A. Valavanis
  • M. Langer
  • H. Pokieser
  • B. Hagen
  • W. Rodl
Article
  • 18 Downloads

Abstract

The safety, tolerance and efficacy of the non-ionic dimer iotrolan 280 in head and body computed tomography was compared with iohexol, iopamidol and iopromide in a double-blind, randomized, multicenter study. A total of 307 head and 261 body examinations were performed. No significant changes in liver or renal blood parameters were seen up to 24 h post-examination. No significant differences in tolerability, adverse events profile, and efficacy were seen.

Key words

Iotrolan Contrast agents CT Radiology, study 

References

  1. 1.
    Kennedy C, Rickärds D, Lee S, Harp MB, Dawson P (1988) A double-blind study comparing the efficiency, tolerance and renal effects of iopromide and iopamidol. Br J Radiol 61: 288–293PubMedGoogle Scholar
  2. 2.
    Langer M, Langer R, Zwicker C, Speck U, Jänicke U-A, Felix R (1991) Clinical and nephrologic tolerance of iopromide and iotrolan in computed tomography. Invest Radiol 26: 83–85Google Scholar
  3. 3.
    Gross-Fengels W, Neufang KFK, Siebert CH, Lanfermann H, Steinbrich W (1990) Unerwünschte Kontrastmittelnebenwirkungen bei der i. v. DSA — Vergleich von zwei nichtionischen Kontrastmitteln. Röntgen-Blätter 43: 144–149Google Scholar
  4. 4.
    Bernardino ME, Fishman EK, Jeffrey RG, Brown PC (1992) Comparison of iohexol 300 and diatrizoate meglumine 60 for body CT: image quality, adverse reactions, and aborted/repeated examinations. Am J Radiol 156: 665–667Google Scholar
  5. 5.
    Wolf GL, Arenson RL, Cross AP (1989) A prospective trial of ionic vs non-ionic contrast agents in routine clinical practice: comparison of adverse effects. Am J Radiol 152: 939–944Google Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • O. Schubiger
    • 1
  • M. Friedrich
    • 2
  • A. Valavanis
    • 3
  • M. Langer
    • 4
  • H. Pokieser
    • 5
  • B. Hagen
    • 6
  • W. Rodl
    • 7
  1. 1.Department of NeuroradiologieKlinik im ParkZürichSwitzerland
  2. 2.Röntgenabteilung, Krankenhaus am UrbanBerlinGermany
  3. 3.Institut für NeuroradiologieUniversitätsspitalZürichSwitzerland
  4. 4.Radiologische UniversitätsklinikFreiburgGermany
  5. 5.Zentrales Institut für Röntgendiagnostik der UniversitätWienAustria
  6. 6.Röntgenabteilung, Martin-Luther-KrankenhausBerlinGermany
  7. 7.Röntgenabteilung, Medizinische UniversitätsklinikErlangenGermany

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