Abstract
Between 1973–1982, the Hungarian Congenital Malformation Registry recorded 165 male index patients with two or moregenitalanomalies of themale (GAM) without other abnormalities. Of 17 ‘severe’ GAM cases with penile or perineal hypospadias and other anomalies of external genitalia, clinical examination detected a recognizable syndrome in all but one case. A family study of 70 ‘mild’ GAM cases with coronal or glandular hypospadias, undescended testes, and congenital inguinal hernia with or without minor genital anomalies, showed that 8.7% of index patients had fathers and brothers with GAM-type anomalies. The mild GAM cases seem to be a monotopic developmental field defect, the so-called GAM-complex.
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Abbreviations
- GAM:
-
genital anomalies of males
- MCA:
-
multiple congenital abnormality
- CA:
-
congenital abnormality
References
Bod M, Czeizel A (1971) Congenital malformation surveillance. Teratology 24:277–283
Czeizel A (1981) Definition of multiple congenital abnormalities. Acta Morphol Acad Sci Hung 29:251–258
Czeizel A, Tusnády G (1984) Aetiological studies of isolated common congenital abnormalities in Hungary. Akadémiai Kiadó, Budapest
Czeizel A, Kiss P, Pazonyi I, Osztovics M (1978) Nationwide investigation of multiple malformations. Acta Paediatr Acad Sci Hung 19:275–280
Czeizel A, Telegdi L, Tusnády G (1987) Multiple congenital abnormalities. Akadémiai Kiadó, Budapest
Opitz JM (1982) The developmental field concept in clinical genetics. J Pediatr 101:805–809
Pfaundler M, von Seht L (1922) Über Syntropie von Krankheitszuständen. Z Kinderheilk 30:100–104
Scorer CG (1955) Descent of the testicle in the first year of life. Br J Urol 27:374–379
Scorer CG (1964) The descent of the testis. Arch Dis Child 39:605–610
Spranger J, Benirschke K, Hall JG, Lenz W, Lowry RB, Opitz JH, Pinsky L, Schwarzacher HG, Smith DW (1982) Errors of morphogenesis: concepts and terms. J Pediatr 100:160–165
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Czeizel, A. Genital anomalies of males (GAM-complex). Eur J Pediatr 146, 181–183 (1987). https://doi.org/10.1007/BF02343229
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DOI: https://doi.org/10.1007/BF02343229