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European Journal of Pediatrics

, Volume 146, Issue 2, pp 113–122 | Cite as

Interaction between endocrine and paracrine peptides in prenatal growth control

  • R. D. G. Milner
  • D. J. Hill
Review

Abstract

The evidence reviewed here shows that the endocrinology of fetal growth is very different from that operating postnatally. Pituitary hormones play little part in stimulating growth of the lean body mass or skeleton although growth hormone (GH) may be involved, in some as yet ill defined way in the ontogeny of the fetal pancreatic islet and insulin secretion. Insulin is important because it stimulates fetal cellular anabolism but acts in a permissive manner: with too little insulin growth is inhibited, with too much growth proceeds at a genetically predetermined rate. Placental lactogen (PL), or other peptides within the GH/PL family, may act as a true growth-promoting hormone in the fetus; it stimulates both cellular metabolism and mitosis. The part played by endocrine control mechanisms in the fetus is set in context by an appreciation of the importance of locally acting tissue growth factors, and in particular the somatomedins. Their part in fetal growth control is intimately bound up with the plane of nutrition experienced by the fetus. It is concluded that the simplest analysis that makes biological sense involves a consideration of hormones, tissue growth factors and nutrition, not hierarchically but as mutually interacting variables.

Key words

Prenatal growth Nutrition Insulin Placental lactogen Tissue growth factors 

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References

  1. 1.
    Adams SO, Nissley SP, Handwerger S, Rechler MM (1983) Development patterns of insulin-like growth factor I and II synthesis and regulation in rat fibroblasts. Nature 302:150–153PubMedCrossRefGoogle Scholar
  2. 2.
    Anderson HJ (1961) Studies of hypothyroidism in children. Acta Paediatr Scand 50 [Suppl 125]:1–50Google Scholar
  3. 3.
    Andersson I, Billig H, Fryklund L, Hansson HA, Isaksson O, Isgaard J, Nilsson A, Rozell B, Scottner A, Stemme S (1986) Localization of IGFI in adult rats. Immunohistochemical studies. Acta Physiol Scand 126:311–312PubMedGoogle Scholar
  4. 4.
    Barcroft J (1946) Researches in perinatal life. Blackwell, OxfordGoogle Scholar
  5. 5.
    Baroffio A, Raddatz E, Markert M, Kucera P (1986) Transient stimulation of glucose metabolism by insulin in the 1-day chick embryo. J Cell Physiol 127:288–292PubMedCrossRefGoogle Scholar
  6. 6.
    Barrera-Saldena HA, Seeburg PH, Saunders GF (1983) Two structurally different genes produce the same secreted human placental lactogen hormone. J Biol Chem 25:3787–3793Google Scholar
  7. 7.
    Barsh GS, Seeburg PA, Gelinas RE (1984) The human growth hormone gene family: structure and evolution of the chromosomal locus. Nucleic Acids Res 11:3939–3958Google Scholar
  8. 8.
    Bassas L, De Pablo F, Lesniak M, Roth J (1985) Ontogeny of receptors for insulin-like peptides in chick embryo tissues: early dominance of insulin-like growth factor over insulin receptors in brain. Endocrinology 117:2321–2329PubMedGoogle Scholar
  9. 9.
    Benzo CA, Green TD (1974) Functional differentiation of the chick endocrine pancreas: insulin storage and secretion. Anat Rec 180:491–496PubMedCrossRefGoogle Scholar
  10. 10.
    Biggazi M, Ronga R, Lancranjan I, Ferraro S, Branconi F, Buzzoni P, Martorana G, Scarselli GF, Del Pozo E (1979) A pregnancy in an acromegalic woman during bromocriptine treatment: effects on growth hormone and prolactin in the maternal, fetal and amniotic compartments. J Clin Endocrinol Metab 48:9–12Google Scholar
  11. 11.
    Blethen SL, White NH, Santiago JV, Daughaday WH (1981) Plasma somatomedins endogenous insulin secretion and growth in transient neonatal diabetes mellitus. J Clin Endocrinol Metab 52:144–147PubMedGoogle Scholar
  12. 12.
    Blundell TL, Bedarkar S, Rinderknecht E, Humbel RE (1978) Insulin-like growth factors: a model for tertiary structure accounting for immunoreactivity and receptor binding. Proc Natl Acad Sci USA 75:180–184PubMedGoogle Scholar
  13. 13.
    Colenbrander B, Van Rossum-kok CMJE, Van Straaten HWM, Wensing CJG (1979) The effect of fetal decapitation on the testis and other endocrine organs in the pig. Biol Reprod 20:198–204PubMedCrossRefGoogle Scholar
  14. 14.
    Conover CA, Rosenfeld RE, Hintz RL (1986) Hormonal control of the replication of human fetal fibroblasts: role of somatomedin-C/insulin-like growth factor I. J Cell Physiol 128:47–54PubMedCrossRefGoogle Scholar
  15. 15.
    Cooke PS, Nicoll CS (1984) Role of insulin in the growth of fetal rat tissues. Endocrinology 114:638–643PubMedGoogle Scholar
  16. 16.
    Cooke PS, Russel SM, Nicoll CS (1983) A transplant system of studying hormonal control of growth of fetal rat tissues: effects of hypophysectomy, growth hormone, prolactin and thyroxine. Endocrinology 112:806–812PubMedGoogle Scholar
  17. 17.
    Crace CJ, Hill DJ, Milner RDG (1984) Mitogenic actions of insulin on fetal and neonatal rat cells in vitro. J Endocrinol 104: 63–68Google Scholar
  18. 18.
    Daughaday WH, Trivedi B, Kapadia M (1979) The effect of hypophysectomy on rat chorionic somatomammotrophin as measured by prolactin and growth hormone radioreceptor assays: possible significance in maintenance of somatomedin generation. Endocrinology 105:210–214PubMedGoogle Scholar
  19. 19.
    De Noto FM, Moore DD, Goodman HM (1981) Human growth hormone DNA sequence and mRNA structure: possible alternative splicing nucleic acids. Research 9:3719–3730Google Scholar
  20. 20.
    De Prins FA (1987) PhD thesis. University of Leuven, BelgiumGoogle Scholar
  21. 21.
    De Prins FA, Van Assche A, Milner RDG (1983) C-peptide levels in amniotic fluid in experimental fetal growth retardation. Biol Neonate 43:186–190Google Scholar
  22. 22.
    De Prins FA, Hill DJ, Fekete M, Robsen DJ, Fieller NRJ, Van Assche FA, Milner RDG (1984) Reduced plasma somatomedin activity and sulphate incorporation by costal cartilage in vitro during experimental growth retardation in the fetal rat. Pediatr Res 18:1100–1104PubMedGoogle Scholar
  23. 23.
    D'Ercole AJ, Applewhite GT, Underwood LE (1980) Evidence that somatomedin is synthesized by multiple tissues in the fetus. Dev Biol 75:315–328PubMedGoogle Scholar
  24. 24.
    D'Ercole AJ, Bose CL, Underwood LE, Lawson EE (1984) Serum somatomedin-C concentrations in a rabbit model of diabetic pregnancy. Diabetes 33:590–595PubMedGoogle Scholar
  25. 25.
    D'Ercole AJ, Stiles AD, Underwood LE (1984) Tissue concentrations of somatomedin-C: further evidence for multiple sites of synthesis and paracrine/autocrine mechanism of action. Proc Natl Acad Sci USA 81:935–939PubMedGoogle Scholar
  26. 26.
    D'Ercole AJ, Hill DJ, Strain AJ, Underwood LE (1986) Tissue and plasma somatomedin-C/insulin like growth factor I (SM-C/IGF-I) concentrations in the human fetus during the first half of gestation. Pediatr Res 20:253–255PubMedGoogle Scholar
  27. 27.
    Diczfalusy E (1969) Steroid metabolism in the human foetoplacental unit. Acta Endocrinol (Copenh) 61:649–664Google Scholar
  28. 28.
    Eguchi Y (1961) Atrophy of the fetal mouse adrenal following decapitation in utero. Endocrinology 68:716–719PubMedGoogle Scholar
  29. 29.
    Fant ME, Munro HN, Moses AC (1986) An autocrine/paracrine role for insulin like growth factors in the regulation of human placental growth. J Clin Endocrinol Metab 63:499–505PubMedGoogle Scholar
  30. 30.
    Fekete M, Hill DJ, Milner RDG (1983) Somatomedin activity and cartilage [35S] sulphate incorporation in the growth retarded neonatal rat. Biol Neonate 44:114–122PubMedGoogle Scholar
  31. 31.
    Fennoy I, Eisen HJ, White RM (1983) The potential of insulin as a regulator of fetal somatomedin production. In: Spencer EM (ed) Insulin-like growth factors/somatomedins. Basic chemistry, biology and clinical importance. de Gruyter, Berlin, pp 357–364Google Scholar
  32. 32.
    Filippi G, McKusick VA (1970) The Beckwith-Wiedemann syndrome. Medicine 49:279–298PubMedGoogle Scholar
  33. 33.
    Fletcher JM, Falconer J, Bassett JM (1982) The relationship of body, placental weight to plasma levels of insulin and other hormones during development in fetal rabbits. Diabetologia 23: 124–130PubMedCrossRefGoogle Scholar
  34. 34.
    Fowden A, Comline RS (1984) The effects of pancreatectomy on the sheep fetus in utero. Q J Exp Physiol 69:319–330PubMedGoogle Scholar
  35. 35.
    Francis MJO, Hill DJ (1975) Prolactin-stimulated production of somatomedin by rat liver. Nature 255:167–168PubMedCrossRefGoogle Scholar
  36. 36.
    Frankenne F, Hennen G, Parks JS, Nielsen PV (1986) A gene deletion in the hGH/hCS gene cluster could be responsible for the placental expression of hGH and/or hCS molecules absent in normal subjects. Endocrinology 118 [suppl]:128Google Scholar
  37. 37.
    Freemark M, Handwerger S (1983) Ovine placental lactogen, but not growth hormone, stimulates amino acid transport in fetal rat diaphragm. Endocrinology 112:402–404PubMedGoogle Scholar
  38. 38.
    Freemark M, Handwerger S (1985) Synergistic effects of ovine placental lactogen and insulin on glycogen metabolism in fetal rat hepatocytes. Am J Physiol 247:E714-E718Google Scholar
  39. 39.
    Freemark M, Handwerger S (1986) The glycogenic effects of placental lactogen and growth hormone on ovine fetal liver are mediated through binding to specific fetal ovine placental lactogen receptors. Endocrinology 118:613–618PubMedGoogle Scholar
  40. 40.
    Freinkel N, Metzger BE (1979) Pregnancy as a tissue culture experience: the critical implications of maternal metabolism for fetal development. In: Elliott K, O'Connor M (eds) Pregnancy metabolism, diabetes and the fetus. Ciba Found Symp 63. Excerpta Medica, Amsterdam, pp 3–28Google Scholar
  41. 41.
    Furlanetto RW, Underwood LE, Van Wyk JJ, Handwerger S (1978) Serum immunoreactive somatomedin-C is elevated in late pregnancy. J Clin Endocrinol Metab 47:695–698PubMedGoogle Scholar
  42. 42.
    Girard JR, Rieutort M, Kervran A, Jost A (1976) Hormonal control of fetal growth with particular reference to insulin and growth hormone. In: Rooth G, Brateby LE (eds) Perinatal medicine. Almquist and Wicksell, Stockholm, pp 197–202Google Scholar
  43. 43.
    Glassock GF, Nicoll CS (1981) Hormonal control of growth in the fetal rat. Endocrinology 109:176–184Google Scholar
  44. 44.
    Gluckman PD (1987) The role of pituitary hormones, growth factors and insulin in the regulation of fetal growth. In: Clarke JR (ed) Oxford reviews of reproductive biology no. 8. Oxford University Press, London (in press)Google Scholar
  45. 45.
    Gluckman PD, Butler JH (1985) Circulating insulin-like growth factor-I and-II concentrations are not dependent on pituitary influences in the midgestation fetal sheep. J Dev Physiol 7:405–409PubMedGoogle Scholar
  46. 46.
    Gluckman PD, Kaplan SL, Rudolph AM, Grumbach MM (1979) Hormone ontogeny in the ovine fetus. II. Ovine chorionic somatomammotropin in mid and late gestation in the fetal and maternal circulations. Endocrinology 104:1828–1833PubMedGoogle Scholar
  47. 47.
    Gluckman PD, Grumbach MM, Kaplan SL (1981) The neuroendocrine function and regulation of growth hormone and prolactin in the mammalian fetus. Endocr Rev 2:363–395PubMedGoogle Scholar
  48. 48.
    Gluckman PD, Butler J, Elliott J (1983) The ontogeny of somatotropic binding sites in ovine hepatic membranes. Endocrinology 112:1607–1612PubMedGoogle Scholar
  49. 49.
    Grumbach MM, Kaplan SL (1973) Ontogenesis of growth hormone, insulin, prolactin and gonadotropin secretion in the human fetus. In: Comline RS, Dawes GS, Nathanielsz PW (eds) Foetal and neonatal physiology. Cambridge University Press, London, pp 462–487Google Scholar
  50. 50.
    Grumbach MM, Kaplan SL, Sciarra JJ, Burr I (1968) Chorionic growth hormone — prolactin (CGP): secretion, deposition, biological activity in man, and postulated function as the ‘growth hormone’ of the second half of pregnancy. Ann N Y Acad Sci USA 148:501–531Google Scholar
  51. 51.
    Heinze E, Thi CN, Vetter U, Fussganger RD (1982) Interrelationship of insulin and somatomedin activity in fetal rats. Biol Neonate 41:240–245Google Scholar
  52. 52.
    Heitz PV, Kloppel G, Hacki WH (1977) Nesidioblastosis: the pathological basis of persistent hyperinsulinaemic hypoglycaemia in infants. Diabetes 26:632–642PubMedGoogle Scholar
  53. 53.
    Hendricks A, De Pablo F, Roth J (1984) Early developmental and tissue-specific patterns of insulin binding in chick embryo. Endocrinology 115:1315–1323PubMedGoogle Scholar
  54. 54.
    Hennen G, Frankenne F, Closset J, Gomez F, Pirens G, El Khayat N (1985) A human placental GH: increasing levels during second half of pregnancy and pituitary GH suppression as revealed by monoclonal antibody radioimmunoassay. Int J Fertil 30:27–33PubMedGoogle Scholar
  55. 55.
    Hill DE (1978) Effect of insulin on fetal growth. Semin Perinatol 2:319–328PubMedGoogle Scholar
  56. 56.
    Hill DJ, Milner RDG (1980) Increased somatomedin and cartilage metabolic activity in rabbit fetuses injected with insulin in utero. Diabetologia 19:143–147PubMedCrossRefGoogle Scholar
  57. 57.
    Hill DJ, Milner RDG (1985) Insulin as a growth factor. Pediatr Res 19:879–886PubMedGoogle Scholar
  58. 58.
    Hill DJ, Milner RDG (1985) The role of peptide hormones and growth factors in the control of fetal growth. In: Chiswick ML (ed) Recent advances in perinatal medicine. Churchill Livingstone, London, pp 79–102Google Scholar
  59. 59.
    Hill DJ, Davidson P, Milner RDG (1979) Retention of plasma somatomedin activity in the fetal rabbit following decaptitation in utero. J Endocrinol 81:93–102PubMedGoogle Scholar
  60. 60.
    Hill DJ, Sheffrin RA, Milner RDG (1982) Raised plasma somatomedin activity and cartilage metabolic activity (35S) suphate uptake in vitro) in the fetus of mildly diabetic pregnant rats. Diabetologia 23:270–274PubMedCrossRefGoogle Scholar
  61. 61.
    Hill DJ, Fekete M, Milner RDG, De Prins F, Van Assche A (1983) Reduced plasma somatomedin activity during experimental growth retardation in the fetal and neonatal rat. In: Spencer EM (ed) Insulin-like growth factors/somatomedins. Basic chemistry, biology and clinical importance. de Gruyter, Berlin, pp 345–352Google Scholar
  62. 62.
    Hill DJ, Crace CJ, Milner RDG (1985) Incorporation of [3H] thymidine by isolated fetal myoblasts and fibroblasts in response to human placental lactogen (HPL): possible mediation of HPL action by release of immunoreactive SM-C. J Cell Physiol 125: 337–344PubMedCrossRefGoogle Scholar
  63. 63.
    Hill DJ, Crace CJ, Nissley SP, Morrell D, Holder AT, Milner RDG (1985) Fetal rat myoblasts release both rat somatomedin-C (SM-C)/insulin like growth factor I (IGF-I) and multiplication stimulating activity in vitro: partial characterization and biological activity of myoblast-derived SM-C/IGF-I. Endocrinology 117:2061–2072PubMedGoogle Scholar
  64. 64.
    Hill DJ, Crace CJ, Strain AJ, Milner RDG (1986) Regulation of amino acid uptake and deoxyribonucleic acid synthesis in isolated human fetal fibroblasts and myoblasts: effect of human placental lactogen, somatomedin-C, multiplication stimulating activity and insulin. J Clin Endocrinol Metab 62:753–760PubMedGoogle Scholar
  65. 65.
    Hill DJ, Frazer A, Swenne I, Wirdnam PK, Milner RDG (1987) Somatomedin-C in the human fetal pancreas: cellular localization and release during organ culture. Diabetes (in press)Google Scholar
  66. 66.
    Hill DJ, Strain AJ, Milner RDG (1987) Growth factors in embryogenesis. In: Clarke JR (ed) Oxford reviews of reproductive biology no. 9. Oxford University Press, London (in press)Google Scholar
  67. 67.
    Hizuka N, Hendricks CM, Pavlakis GN, Hamer DH, Gorden P, (1982) Properties of human growth hormone polypeptides: purified from pituitary extracts and synthesized in monkey kidney cells. J Clin Endocrinol Metab 55:545–550PubMedGoogle Scholar
  68. 68.
    Hochberg Z, Perlman R, Brandes JM, Benderli A (1983) Insulin regulates placental lactogen and estradiol secretion by cultured human term trophoblast. J Clin Endocrinol Metab 57:1311–1313PubMedGoogle Scholar
  69. 69.
    Hoiriis-Nielsen J, Nielson V, Molsted-Pedersen L, Deckert T (1986) Effects of pregnancy hormones on pancreatic islets in organ culture. Acta Endocrinol (Copenh) 111:336–341Google Scholar
  70. 70.
    Holder AT, Wallis M (1977) Actions of growth hormone, prolactin and thyroxine on serum somatomedin-like activity and growth in hypopituitary dwarf mice. J Endocrinol 74:223–229PubMedGoogle Scholar
  71. 71.
    Honnebier WJ, Swaab DF (1974) Influence of α-melanocytestimulating-hormone (α-MSH) growth hormone (GH) and fetal brain extracts on intrauterine growth of fetus and placenta in the rat. Br J Obstet Gynaecol 81:439–447Google Scholar
  72. 72.
    Hubert C, Mondon F, Cedard L (1982) Biological activity and quantification of messenger RNA coding for human chorionic somatomammotropin in normal and intrauterine growth retarded pregnancies. Am J Obstet Gynaecol 144:722–725Google Scholar
  73. 73.
    Hurley TW, D'Ercole AJ, Handwerger S, Underwood LE, Furlanetto RW, Fellows RE (1977) Ovine placental lactogen induces somatomedin: a possible role in fetal growth. Endocrinology 101:1635–1638PubMedGoogle Scholar
  74. 74.
    Isaksson OG, Jansson J, Gause IA (1982) Growth hormone stimulates longitudinal bone growth directly. Science 216:1237–1239PubMedGoogle Scholar
  75. 75.
    Jack PMB, Milner RDG (1975) Effect of decapitation and ACTH on somatic development of the rabbit fetus. Biol Neonate 26:195–204PubMedGoogle Scholar
  76. 76.
    Jack PMB, Milner RDG (1975) Adrenocorticotrophin and the development of insulin secretion in the rabbit foetus. J Endocrinol 64:67–75PubMedGoogle Scholar
  77. 77.
    Jost A (1954) Hormonal factors in the development of the fetus. Cold Spring Harbor Symp Quant Biol 19:167–181PubMedGoogle Scholar
  78. 78.
    Kalkhoff RK, Kim HJ (1979) The influence of hormonal changes of pregnancy on maternal metabolism. In: Beard RW, Hoet JJ (eds) Pregnancy metabolism, diabetes and the fetus. Ciba Found Symp 63. Excerpta Medica, Amsterdam, pp 29–56Google Scholar
  79. 79.
    Kaplan SL, Grumbach MM, Shepard TH (1972) The ontogenesis of human fetal hormones. J Clin Invest 51:3080–3093PubMedGoogle Scholar
  80. 80.
    Kerr GR, Tyson IB, Allen TR, Wallace JH, Scheffler G (1972) Deficiency of thyroid hormone and development of the fetal rhesus monkey. I Effect on physical growth, skeletal maturation and biochemical measures of thyroid function. Biol Neonate 21: 285–295Google Scholar
  81. 81.
    Knuth UA, Friesen HG (1983) Prolactin and pregnancy. In: Martini L, James VH (eds) Current topics in experimental endocrinology, vol 4. Academic Press, New York, pp 69–96Google Scholar
  82. 82.
    Ktorza A, Nurjhan N, Girard JR, Picoh L (1983) Hyperglycaemia induced by glucose infusion in the unrestrained pregnant rat: effect on body weight and lipid synthesis in post mature fetuses. Diabetologia 24:128–130PubMedCrossRefGoogle Scholar
  83. 83.
    Liggins GC, Kennedy PC (1968) Effects of electrocoagulation of the fetal lamb hypophysis on growth and development. J Endocrinol 40:371–381PubMedGoogle Scholar
  84. 84.
    Liggins GC, Fairclough RJ, Grieves SA, Kendall JZ, Knox BS (1973) The mechanism of initiation of parturition in the ewe. Recent Prog Horm Res 29:111–159PubMedGoogle Scholar
  85. 85.
    Merimee TJ, Zapf J, Froesch ER (1982) Insulin-like growth factor in pregnancy: studies in a growth hormone deficient dwarf. J Clin Endocrinol Metab 54:1101–1103PubMedGoogle Scholar
  86. 86.
    Mills NC, Underwood LE, D'Ercole AJ (1985) Expression of insulin-like growth factors (somatomedins) in the human placenta. Endocrinology 116 [Suppl]:268Google Scholar
  87. 87.
    Milner RDG (1979) The role of insulin and glucagon in fetal growth and metabolism. In: Visser HKA (ed) Nutrition and metabolism of the fetus and infant. Martinus Nijhoff, The Hague, pp 3–18Google Scholar
  88. 88.
    Milner RDG (1981) Growth and development of the endocrine pancreas. In: Davis JA, Dobbing J (eds) Scientific foundations of paediatries, 2nd edn. Heinemann, London, pp 701–713Google Scholar
  89. 89.
    Milner RDG (1984) Fetal rat and glucose metabolism. In: Beard RW, Nathanielsz PN (eds) Fetal physiology and medicine, 2nd edn. Marcel Dekker, New York, pp 153–177Google Scholar
  90. 90.
    Milner RDG (1987) Determinants of growth in utero. In: Waterlow JC (ed) 14th Nestlé Nutrition Workshop. Raven Press, New York (in press)Google Scholar
  91. 91.
    Milner RDG, Hill DJ (1984) Fetal growth control: the role of insulin and related peptides. Clin Endocrinol 21:415–433Google Scholar
  92. 92.
    Milner RDG, De Gasparo M, Milner GR, Wirdnam PK (1979) In: Sutherland HW, Stowers JM (eds) Carbohydrate metabolism in pregnancy and the newborn 1978. Springer, Berlin Heidelberg New York, pp 132–151Google Scholar
  93. 93.
    Murphy LJ, Urhovsek E, Lazarus L (1983) Identification and characterization of specific growth hormone receptors in cultured human fibroblasts. J Clin Endocrinol Metab 57:1117–1124PubMedGoogle Scholar
  94. 94.
    Nielsen PV, Pederson H, Kampmann EM (1979) Absence of human placental lactogen in an otherwise unentful pregnancy. Am J Obstet Gynecol 135:322–326PubMedGoogle Scholar
  95. 95.
    Neufeld ND, Kaplan SA, Lippe BM (1981) Monocyte insulin receptors in infants of strictly controlled diabetic mothers. J Clin Endocrinol Metab 52:473–478PubMedGoogle Scholar
  96. 96.
    Obregon MJ, Mallol J, Pastor R, Morreale de Escobar G, Escobar de Rey F (1984)l-thyroxine and 3, 5, 3′-triiodo-l-thyronine in rat embryos before onset of fetal function. Endocrinology 114:305–307PubMedGoogle Scholar
  97. 97.
    Parkes MJ, Hill DJ (1985) Lack of growth hormone-dependent somatomedins or growth retardation in hypophysectomized fetal lambs. J Endocrinol 104:193–199PubMedGoogle Scholar
  98. 98.
    Pedersen J, Bojsen-Moller B, Poulsen H (1954) Blood sugar in newborn infants of diabetic mothers. Acta Endocrinol (Copenh) 15:33–52Google Scholar
  99. 99.
    Picon L (1967) Effect of insulin on growth and biochemical composition of the rat fetus. Endocrinology 81:1419–1421PubMedGoogle Scholar
  100. 100.
    Picon L, Jost A (1963) Teneur du corps en lipides et en protides chez le foetus de rat et de lapin et chez le rat nouveau-né. C R Soc Biol (Paris) 157:1368–1372Google Scholar
  101. 101.
    Posner BI (1974) Insulin receptors in human and animal placental tissue. Diabetes 23:209–217PubMedGoogle Scholar
  102. 102.
    Posner BI (1976) Characterization and modulation of growth hormone and prolactin binding in mouse liver. Endocrinology 98:645–654PubMedGoogle Scholar
  103. 103.
    Potau N, Riudor E, Ballabriga A (1981) Insulin receptors in human placenta in relation to fetal weight and gestational age. Pediatr Res 15:798–803PubMedGoogle Scholar
  104. 104.
    Reusens B, Kuhn ER, Hoet JJ (1979) Fetal plasma prolactin levels and fetal growth in relation to maternal CB-154 treatment in the rat. Gen Comp Endocrinol 39:118–120PubMedCrossRefGoogle Scholar
  105. 105.
    Richman RA, Benedict MR, Florini JR, Toly BA (1985) Hormonal regulation of somatomedin secretion by fetal rat hepatocytes in primary culture. Endocrinology 116:180–188PubMedGoogle Scholar
  106. 106.
    Romanus A, Rabinovitch A, Rechler MM (1985) Neonatal islet cell cultures synthesize insulin-like growth factor. I. Diabetes 34: 696–702PubMedGoogle Scholar
  107. 107.
    Russell SM, Spencer EM (1985) Local injections of human or rat growth hormone or of purified human somatomedin-C stimulate unilateral tibial epiphyseal growth in hypophysectomized rats. Endocrinology 116:2563–2567PubMedGoogle Scholar
  108. 108.
    Sandra A, Przybylski RJ (1979) Ontogeny of insulin binding during chick skeletal myogenesis in vitro. Dev Biol 68:546–556PubMedCrossRefGoogle Scholar
  109. 109.
    Sara VR, Hall K, Misaki M, Fryklund L, Christensen L, Wetteberg L (1983) Ontogenesis of somatomedin and insulin receptors in the human fetus. J Clin Invest 71:1084–1094PubMedGoogle Scholar
  110. 110.
    Schiff D, Colle E, Stern L (1972) Metabolic and growth patterns in transient neonatal diabetes. N Engl J Med 287:119–122PubMedGoogle Scholar
  111. 111.
    Sinha Y, Vanderlaan W (1982) Effect on growth of prolactin deficiency induced in infant mice. Endocrinology 110:1871–1878PubMedGoogle Scholar
  112. 112.
    Spellacy WN (1973) Human placental lactogen in high-risk pregnancy. Clin Obstet Gynecol 16:298–312PubMedGoogle Scholar
  113. 113.
    Steel RB, Mosley JD, Smith CH (1979) Insulin and placenta: degradation and stabilization, binding to microvillous receptors, and amino acid uptake. Am J Obstet Gynecol 135:522–529PubMedGoogle Scholar
  114. 114.
    Strain AJ, Hill DJ, Swenne I, Milner RDG (1986) Stimulation of DNA synthesis in isolated human foetal hepatocytes by insulin like growth factor I, placental lactogen and growth hormone. J Endocrinol [Suppl] 108:142Google Scholar
  115. 115.
    Susa JB, McCormick KL, Widness JA, Singer DB, Oh W, Adamsons K, Schwartz R (1979) Chronic hyperinsulinemia in the fetal rhesus monkey: effects on fetal growth and composition. Diabetes 28:1058–1063PubMedGoogle Scholar
  116. 116.
    Susa JB, Neave C, Sehgal P, Singer DB, Zeller WP, Schwartz R (1984) Chronic hyperinsulinemia in the fetal rhesus monkey: effects of physiological hyperinsulinemia on fetal growth and composition. Diabetes 33:656–660PubMedGoogle Scholar
  117. 117.
    Swaab DF, Honnebier WJ (1973) The influence of removal of the fetal rat brain upon intrauterine growth of the fetus and the placenta and on gestational length. Br J Obstet Gynecol 80: 589–597Google Scholar
  118. 118.
    Swenne I, Hill DJ, Strain AJ, Milner RDG (1987) Growth hormone regulation of somatomedin C/insulin like growth factor I production and DNA replication in fetal rat islets in tissue culture. Diabetes (in press)Google Scholar
  119. 119.
    Thorburn GD (1974) The role of the thyroid gland and kidneys in fetal growth. In: Elliott K, Knight J (eds) Size at birth. Ciba Found Symp 27. Elsevier, Amsterdam, pp 185–200Google Scholar
  120. 120.
    Thorburn GD, Waters MJ, Young IR, Dolling M, Buntine D, Hopkins PS (1981) Epidermal growth factor: a critical factor in fetal maturation? In: Elliott K, Whelan J (eds) The fetus and independent life. Ciba Found Symp 86. Pitman, London, pp 172–198Google Scholar
  121. 121.
    Thorsson AV, Hintz RL (1977) Insulin receptors in the newborn. N Engl J Med 197:908–912Google Scholar
  122. 122.
    Tricoli JY, Rall LB, Scott J, Bell GI, Shows TB (1984) Localization of insulin-like growth factor genes to human chromosomes 11 and 12. Nature 310:784–786PubMedCrossRefGoogle Scholar
  123. 123.
    Van Assche FA, Gepts W, De Gasparo M (1969) The endocrine pancreas in anencephalics: a histological, histochemical and biochemical study. Biol Neonate 14:374–388Google Scholar
  124. 124.
    Vetter U, Zapf J, Heit W, Helbing G, Heinze E, Froesch ER, Teller WM (1986) Human fetal and adult chondrocytes. Effect of insulin-like growth factors I and II, insulin, and growth hormone on clonal growth. J Clin Invest 77:1903–1908PubMedGoogle Scholar
  125. 125.
    Vileisis RA, D'Ercole AJ (1986) Tissue and serum concentrations of somatomedin-C/insulin-like growth factor I in fetal rats made growth retarded by uterine artery ligation. Pediatr Res 20: 126–130PubMedGoogle Scholar
  126. 126.
    Waterfield MD, Scrace T, Whittle N, Stroobant P, Johnsson A, Wasteson A, Westermark B, Heldin CH, Huang JS, Deuel T (1983) Platelet derived growth factor is structurally related to the putative transforming protein of p28SIS of simian sarcoma virus. Nature 304:35–39PubMedCrossRefGoogle Scholar
  127. 127.
    Whitsett JA, Lessard JL (1978) Characteristics of the microvillus brush border of human placenta: insulin receptor localization in brush border membranes. Endocrinology 103:1458–1468PubMedGoogle Scholar
  128. 128.
    Whitsett JA, Johnson CL, Hawkins K (1979) Differences in localization of insulin receptors and adenylate cyclase in the human placenta. Am J Obstet Gynecol 133:204–207PubMedGoogle Scholar
  129. 129.
    Wurzel J, Parks J, Herd J, Nielson P (1982) A gene deletion is responsible for the absence of human chorionic somatomammotropin. DNA 1:251–257PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • R. D. G. Milner
    • 1
  • D. J. Hill
    • 1
  1. 1.Department of PaediatricsUniversity of Sheffield, Children's HospitalSheffieldEngland

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