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Dapiprazole for patients with night haloes after excimer keratectomy

  • Yair Alster
  • Anat Loewenstein
  • Tami Baumwald
  • Isaac Lipshits
  • Moshe Lazar
Cornea

Abstract

• Background: Haloes causing difficulties during night driving are one of the common complications of photorefractive keratectomy (PRK). The presumed reason for this phenomenon is the different refraction of light through the treated and untreated areas of the cornea. Its magnitude is proportional to the ratio between the treated area and pupil size. At nighttime, when the pupil dilates, rays from treated and untreated areas of the cornea reach the retina at different foci and produce haloes. We investigated whether dapiprazole, a miotic α-blocker drug, would be helpful in reducing night haloes in patients after PRK. • Methods: Twenty-four patients who complained of night haloes after PRK participated in our study. All were given dapiprazole 0.5% before night driving. Change in pupil size was recorded, and all patients completed a questionnaire on changes in the severity of haloes after instillation of dapiprazole. • Results: Improvement was described as very significant in five patients, moderate in ten and slight in seven. There was no improvement in two patients. The only side effect was slight irritation, which resolved within 1 h. • Conclusion: Our results demonstrate that dapiprazole improves the subjective discomfort caused by night haloes in post-PRK patients.

Keywords

Public Health Retina Refraction Common Complication Treated Area 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Brogliatti B, Rolle T, Messelod M, Boles Carenini B (1985) A new alpha-blocking agent in the treatment of glaucoma: dapiprazole. Glaucoma 7:232–236Google Scholar
  2. 2.
    Gartry DS, Malcolm G, Kerr-Muir MG, Marshall J (1991) Photorefractive keratectomy with an argon fluoride Excimer laser: a clinical study. 7:420–435Google Scholar
  3. 3.
    Gartry DS, Kerr-Muir MG, Lohmann CP, Marshall L (1992) The effect of topical corticosteroids on refractive outcome and corneal haze after photorefractive keratectomy: A prospective randomized, double blind trial. Arch Ophthalmol 110:944–952PubMedGoogle Scholar
  4. 4.
    Geyer O, Loewenstein A, Shalmon B, Neudorfer M, Lazar M (1995) The additive effect of dapiprazole and pilocarpine. Graefe's Arch Clin Exp Ophthalmol 233:448–451CrossRefGoogle Scholar
  5. 5.
    Lohmann CP, Fitzke FW, O'Brart D, Kerr-Muir MG, Marshall J (1993) Halos — a problem for all myopes? A comparison between spectacles, contact lenses, and photorefractive keratectomy. Refract Corneal Surg 9 [Suppl]:S72-S75PubMedGoogle Scholar
  6. 6.
    O'Brart DPS, Lohmann CP, Fitzke FW, Smith SE, Kerr-Muir MG, Marshall J (1994) Night vision after excimer laser photorefractive keratectomy: haze and halos. Eur J Ophthalmol 4:43–51PubMedGoogle Scholar
  7. 7.
    Reibaldi A (1984) A new alpha blocking agent. Glaucoma 3:255–257Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Yair Alster
    • 1
  • Anat Loewenstein
    • 1
  • Tami Baumwald
    • 1
  • Isaac Lipshits
    • 2
  • Moshe Lazar
    • 1
  1. 1.Department of Ophthalmology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael
  2. 2.Assutah Laser CenterTel-AvivIsrael

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