Summary
As has been shown, the guinea pig is not rich in lymphoid tissue. Peyer's patches are not numerous, there is no appendix and no lymphoid sac. Guinea pigs differ from other animals which have been studied in having macrophages in the stroma of the mucosa. These macrophages are confined to the intracellular space of the reticular syncitium and are present in the fetuses, newborn animals, and adults. Desquamation of the cellular epithelium is a characteristic of guinea pigs. The epithelium forms, short tubes on the apices of the villi. Only a few cells are detached from the apices of the villi into the intestinal lumen.
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Gadzhieva, Z.M. Functional and morphological features of the mucous membrane of the guinea pig small intestine. Bull Exp Biol Med 56, 1285–1288 (1963). https://doi.org/10.1007/BF02342841
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DOI: https://doi.org/10.1007/BF02342841