Summary
Investigations carried out demonstrated that thermostable and autoclave-heated allergen fractions prepared from the fluid decanted from the hemolytic streptococcus culture transformed the allergenicity of Streptococcus viridans in the hemolytic direction, passing to it the type-specific M-substance of the donor.
Detection of the transforming action of protein substances, precipitated from the decanted fluid by means of acetic acid, filtered through bacterial filters and heated at 1.5 atmospheric pressure for 30 min (which had a destructive effect on the DNA) pointed to determinative significance of the protein antigenic complexes. This leads to a conclusion that in the development of immunity and allergy in animals and human beings the transformation mechanism is the same, the difference being that in the latter case the plasma cells of reticuloendothelial system serve as the recipient.
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Literature Cited
E. I. Gudkova and P. P. Sakhorov, Byull. Éksper. Biol. (1957), No. 10, p. 81.
V. M. Polshkova, Byull. Éksper. Biol. (1963), 4, p. 66.
P. P. Sakhorov, E. I. Gudkova, V. B. Bureva et al., Agrobiologiya Byull. Éksper. Biol. (1959), 3, p. 362.
P. P. Sakharov, E. I. Gudkova, V. M. Polshkova et al., Byull Éksper. Biol. (1961), 10, p. 80.
H. E. Alexander and G. J. Leidy, J. exp. Med. (1941),93,p. 345.
O. T. Avery, C. M. MacLeod, and M. McCarty, Ibid (1944),79, p. 137.
F. M. Burnet, Enzyme, Antigen and Virus, Cambridge (1956).
Idem, F. M. Burnet, Principles of Animal Virology, New York (1960).
W. K. Ehrich, Handbuch der allgemeinen Pathologie, Berlin (1956),7, p. 1.
H. Ephrussi-Taylor, Exp. Cell. Res. (1951),2, p. 589.
R. D. Hotchkis, Unités biologiques douces de continuité génétique, Paris (1949), p. 57.
Idem, Cold Spr. Harb. Symp. quant. Biol. (1951),16, 457.
Idem, Phosphorus Metabolism, Baltimore (1952),2, p. 426.
Idem, R. D. Hotchkis, The Chemical Basis of Inheritance [in Russian], Moscow (1960), 251.
F. Jacob and E. Wolman, The Chemical Basis of Inheritance [in Russian], Moscow (1960), p. 376.
A. Kleczkowski, Erit. J. exp. Path. (1940),21, p. 98.
H. S. Lawrence, Cellular and Humoral Aspects of Hypersensitive States, New York (1959).
J. Marrack, The Chemistry of Antigens and Antibodies, London (1938).
E. Rajka, Allergie und allergische Erkrankungen, Budapest (1957),1
R. S. Schweet and R. D. Owen, J. cell comp. Physiol. (1957),50, Suppl. 1 p. 199.
J. Smolens and H. Warner, J. Immunol. (1952),68, p. 185.
F. Jacob and E. Wolman, The Chemical Basis of Inheritance [in Russian], Moscow (1960), p. 376.
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Polshkova, V.N., Sakharov, P.P. A study of the transforming properties of allergens. Bull Exp Biol Med 56, 1271–1273 (1963). https://doi.org/10.1007/BF02342837
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DOI: https://doi.org/10.1007/BF02342837