Summary
The effect of nanophyne, gangleron, and pachycarpine on the background bioelectric activity, and on the activating and convulsant effects of nicotine were investigated in expertments on 70 rabbits with the brain intact and on cats with trigeminal section of the brain stem. The degree of the EEG changes depended on the rate of administration of the preparations.
With sufficiently slow administration (about 3 mg/kg/min) there was no change in the character of the background activity. In doses of 5–10 mg/kg gangleron and phosphyne possessed a marked central nicotinolytic effect, but it was manifested only in the blocking of the convulaive effect of nicotine: the activation reaction caused by nicotine was retained. These drugs also did not block the activation reaction caused by the acourtic stimulation or electric stimulation of the sciatic nerve. The anticonvulsant effect of pachycarpine proved to be weak and inconstant. The data obtained suggest that different neurochemical mechanisms underlie the convulsive and activating effects of nicotine.
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Il'yuchenok, R.Y., Ostrovskaya, R.U. & Vinnitskii, I.M. Effect of nanophyne, pachycarpine, and gangleron on the activating and convulsant effects of nicotine. Bull Exp Biol Med 56, 1252–1255 (1963). https://doi.org/10.1007/BF02342832
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DOI: https://doi.org/10.1007/BF02342832