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A study of the penetration of certain cholinolytic drugs through the blood-brain barrier by perfusing the cerebral ventricles

  • Pharmacology
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Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A method of perfusion of cerebral ventricles was used to study the penetration of choliolytics through the blood-brain barrier (BBB) of cats. 30 min after injecting cholinolytics in a dose of 4 mg/kg into the carotid artery the average penetration through the BBB of amizil was 9 μg (±0∶35) and of atropine−4.6 μg (±0.26), whereas lachesine did not penetrate through the BBB at all. These data indicate that there is a difference in penetration through the BBB not only between the tertiary and quaternary cholinolytics, but also between various tertiary cholinolytics.

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Authors and Affiliations

  1. Laboratory of Pharmacology, Institute of Toxicology, Ministry of Health of the USSR, Leningrad

    S. N. Golikov & V. A. Pechenkin

Authors
  1. S. N. Golikov
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  2. V. A. Pechenkin
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Golikov, S.N., Pechenkin, V.A. A study of the penetration of certain cholinolytic drugs through the blood-brain barrier by perfusing the cerebral ventricles. Bull Exp Biol Med 56, 1249–1251 (1963). https://doi.org/10.1007/BF02342831

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  • DOI: https://doi.org/10.1007/BF02342831

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