Summary
The body temperature was reduced in dogs to 7–13°C by general cooling of the body. The first experimental series demonstrated that with the aid of deep hypothermia in a number of animals (in 5 of 23) it was possible to prolong to 2 hours the period of clinical death from acute blood loss with subsequent complete restoration of the vital functions. However, the majority of the animals of this group either could not be revived at all or died 1 to 2 days after the experiment.
Imperfect perfusion during revival, leading to acute dilatation of the heart, marked hemodynamic disturbances occurring during the restoration period in revived dogs, and severe metabolic acidoses, lasting hours during the period of recovery from hypothermia, inhibited subsequent restitution, leading to severe changes in the internal organs and the brain.
Control of the aforementioned factors, as well as intra-arterial infusion of fresh donor's blood and exchange transfusion, employed during the later stages of revival, promoted a more rapid and complete restoration of the vital functions in the 2nd group of animals. All 8 dogs of this group were revived, complete restoration of the vital functions being achieved in 5 animals.
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Negovskii, V.A., Soboleva, V.I., Gurvich, N.L. et al. Deep hypothermia as a method of prolonging clinical death. Bull Exp Biol Med 56, 1206–1209 (1963). https://doi.org/10.1007/BF02342820
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DOI: https://doi.org/10.1007/BF02342820