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Class II HLA DNA polymorphisms in Type 1 (insulin-dependent) diabetic patients of North Indian origin

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Summary

Genetic associations with Type 1 (insulin-dependent) diabetes may be primary or secondary to linkage disequilibrium. Studies of different racial groups should allow these to be distinguished. We have reported that Type 1 diabetes is associated with HLA-DR3 and -DR4 in subjects of North Indian (Punjab) origin and now present the results of a study of HLA class II DNA polymorphisms in this group and in white caucasoid subjects. DR4 in North Indian Type 1 diabetic patients was associated with DQβ and DXα DNA polymorphisms identical to those found in DR4-positive white caucasoid patients. This DQβ/DXα pattern was increased in frequency in North Indian diabetic patients vs control subjects (33.3% vs 8.5%,p<0.001, relative risk=5.12 (95% confidence limits: 1.96–13.4)). A DQβ polymorphism with very low relative risk for Type 1 diabetes in white caucasoid subjects was also markedly reduced in North Indian diabetic patients vs control subjects (2.3% vs 24.7%,p<0.02, relative risk = 0.10 (95% confidence limits: 0.02–0.46)). This pattern was associated with DR2 in white caucasoid subjects, but with DRw6 in North Indians. A DR3-associated DRβ polymorphism was markedly increased in North Indian diabetic patients vs control subjects (90.2% vs 40.7%,p<10−6, relative risk = 12.1 (95% confidence limits: 4.32–33.9)). The DQ subregion may be a primary site of genetic influence on susceptibility to Type 1 diabetes. Further studies in different racial groups will clarify the HLA associations of Type 1 diabetes.

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Authors and Affiliations

  1. Department of Medicine, University of Birmingham, Birmingham, UK

    J. Fletcher, O. Odugbesan & A. H. Barnett

  2. Department of Immunology, University of Birmingham, Birmingham, UK

    C. Mijovic, E. Mackay & A. R. Bradwell

  3. East Birmingham Hospital, Birmingham, UK

    O. Odugbesan & A. H. Barnett

Authors
  1. J. Fletcher
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  2. O. Odugbesan
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  3. C. Mijovic
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  4. E. Mackay
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  5. A. R. Bradwell
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  6. A. H. Barnett
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Fletcher, J., Odugbesan, O., Mijovic, C. et al. Class II HLA DNA polymorphisms in Type 1 (insulin-dependent) diabetic patients of North Indian origin. Diabetologia 31, 343–350 (1988). https://doi.org/10.1007/BF02341501

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  • DOI: https://doi.org/10.1007/BF02341501

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