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The subjective experience of time during lysergic acid diethylamide (LSD-25) intoxication

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Summary

A brief review of the literature in relation to time disorder and LSD-25 is given. Twenty nine patients were studied as regards their time experiences under LSD-25. Eight patients reported an altered time experience following the initial administration of the drug. Twelve patients who had not developed a time disturbance in their initial administration, received LSD-25 a second time at increased dosage, 5 of these patients then experienced a time disturbance.

There was a tendency for time disorder to be associated with visual perceptual changes and for it to occur in the non-schizophrenics. Time disorder was considered to be a non-specific response. Recent views on the nature and genesis of time disorders are discussed.

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References

  • Anastasopoulos, G., andH. Photiades: Effect of LSD-25 on relatives of schizophrenic patients. J. ment. Sci.108, 95–98 (1962).

    CAS  PubMed  Google Scholar 

  • Anderson, E. W., andK. Rawnsley: Clinical studies of lysergic acid diethyamide. Mschr. Psychiat. Neurol.128, 35–55 (1954).

    Google Scholar 

  • Aronson, H., andA. S. Silverstein: The influence of LSD-25 on subjective time. Arch. gen. Psychiat.1, 469–472 (1959).

    CAS  PubMed  Google Scholar 

  • Becker, A. M.: Zur Psychopathologie der Lysergsäurediäthylamidwirkung. Wien. A. Nervenheilk.2, 402–440 (1949).

    Google Scholar 

  • Bennett, C. C.: In:L. Uhr, andJ. G. Miller (eds.), Drugs and behaviour, chapt. 50. New York: Wiley 1960.

    Google Scholar 

  • Beringer, K.: Der Meskalinrausch. Seine Geschichte und Erscheinungsweise. Berlin: Springer 1927.

    Google Scholar 

  • Deshon, H. J., M. Rinkel, andH. C. Solomon: Mental changes experimentally produced by LSD-25. Psychiat. Quart.26, 33–54 (1952).

    Article  CAS  PubMed  Google Scholar 

  • Finney, D. J.: The Fisher-Yates test of significance in 2 × 2 contingency tables. Biometrika35, 145–156 (1948).

    Google Scholar 

  • Fischer, R., E. Griffin andL. Liss: Biological aspects of time in relation to (model) psychoses. Ann. N.Y. Acad. Sci.96 (Art. 1), 44–65 (1962).

    CAS  PubMed  Google Scholar 

  • Greiner, R. T., N. R. Burch andR. Edelberg: Psychopathology and psychophysiology of minimal LSD-25 dosage. Arch. Psychiat. Neurol.79, 208–210 (1958).

    CAS  Google Scholar 

  • Guttmann, E., andW. S. Maclay: Mescalin and depersonalization. J. Neurol. Psychopath.16, 193–212 (1936).

    Google Scholar 

  • Hoagland, H.: Problems of consciousness. Trans. 1st. Conf., p. 164–200,H. A. Abramson (ed.). New York: Josiah Macy Jr. 1950.

    Google Scholar 

  • Hoch, P., J. P. Cattell, andH. H. Pennes: Effects of mescaline and lysergic acid (d. LSD-25). Amer. J. Psychiat.108, 579–584 (1952).

    CAS  PubMed  Google Scholar 

  • Horita, A., andJ. M. Dille: Pyretogenic effect of lysergic acid diethylamide. Science120, 1100–1101 (1954).

    CAS  PubMed  Google Scholar 

  • —, andJ. H. Gogerty: The pyretogenic effect of 5 hydroxytryptophan and its comparison with that of LSD-25. J. Pharmacol. exp. Ther.122, 195–200 (1958).

    CAS  PubMed  Google Scholar 

  • Knauer, A. W., andW. J. M. A. Maloney: A preliminary note on the psychic action of mescalin, with special reference to the mechanism of visual hallucination. J. nerv. ment. Dis.40, 425–436 (1913).

    Google Scholar 

  • Lindeman, E., andW. Malamud: Experimental analysis of the psychopathological effects of intoxicating drugs. Amer. J. Psychiat.90, 853–881 (1934).

    Google Scholar 

  • Mayer-Gross, W.: Experimental psychoses and other mental abnormalities produced by drugs. Brit. med. J.1951II, 317–321.

  • Mitchell, S. W.: The effects of anhalonium lewinii (The mescal Button). Brit. med. J.1896II, 1625–1629.

  • Schneider, K.: Psychopathic personalities (Trans. M. W. Hamilton), 9th edit. London: Cassell 1958.

    Google Scholar 

  • Serko, A.: Im Mescalinrausch. Jb. Psychiat. Neurol.34, 355–366 (1913).

    Google Scholar 

  • Sloane, B., andJ. W. Doust: Psychophysiological investigations in experimental psychoses. Results of the exhibition ofd-lysergic acid diethylamide to psychiatric patients. J. ment. Sci.100, 129–142 (1954).

    CAS  PubMed  Google Scholar 

  • Stoll, W. A.: Lysergsäure-diäthylamid ein Phantasticum aus der Mutterkorngruppe. Schweiz. Arch. Neurol. Psychiat.60, 279–323 (1947).

    Google Scholar 

  • Weiner, H., andS. Ross: Effects ofd-amphetamine sulfate on time and brightness perception in human subjects. Psychopharmacologia (Berl.)3, 44–50 (1962).

    Article  CAS  Google Scholar 

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Kenna, J.C., Sedman, G. The subjective experience of time during lysergic acid diethylamide (LSD-25) intoxication. Psychopharmacologia 5, 280–288 (1964). https://doi.org/10.1007/BF02341260

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  • DOI: https://doi.org/10.1007/BF02341260

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