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Longterm meningeal involvement as the only clinical manifestation of low grade malignant non-Hodgkin's lymphoma

Summary

We present the case of a 56-year old man who developed -at the age of 46-paraesthesia and numbness in the perianal region, the feet and lower legs accompanied by the presence of B-lymphocytes in the cerebrospinal fluid (CSF). Despite intensive work-up an explanation was not found until he developed hepato-splenomegaly ten years after the initial symptoms. Haematologic evaluation at that time disclosed a low-grade malignant B-cell lymphoma. Repeated CSF examination revealed 31 leukocytes/mm3, of which were mainly lymphocytes. These proved to be B-lymphocytes of monoclonal origin.

These findings suggest that a leptomeningeal localisation of a low-grade malignant lymphoma had been present for ten years before systemic manifestation of the disease.

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References

  1. 1.

    Herman TS, Hammond N, Jones SE, Butler JJ, Byrne GE, Mc Kelvey EM: Involvement of the central nervous system by non-Hodgkin's lymphoma. Cancer 43: 390–397, 1979

    PubMed  Article  CAS  Google Scholar 

  2. 2.

    Levitt LJ, Dawson DM, Rosenthal DS, Moloney WC: CNS involvement in the non-Hodgkin's lymphoma. Cancer 45: 545–552, 1980

    PubMed  Article  CAS  Google Scholar 

  3. 3.

    Korsager S, Laursen B, Mortensen TM: Dementia and central nervous system involvement in chronic lymphocytic leukemia. Scand J Haematol 29: 283–286, 1982

    PubMed  Article  CAS  Google Scholar 

  4. 4.

    Boogerd W, Vroom TM: Meningeal involvement as the initial symptom of B-cell chronic lymphocytic leukemia. Eur Neurol 25: 461–464, 1986

    PubMed  Article  CAS  Google Scholar 

  5. 5.

    Cash J, Fehir KM, Pollack MS: Meningeal involvement in early stage chronic lymphocytic leukemia. Cancer 59: 798–800, 1987

    PubMed  Article  CAS  Google Scholar 

  6. 6.

    Reske-Nielsen E, Hoffmann Petersen J, Søgaard H, Jensen KB: Leukaemia of the central nervous system. Lancet I: 211–212, 1974

    Article  Google Scholar 

  7. 7.

    Wilder-Smith E, Roelcke U: Meningopolyradiculitis (Bannwarth syndrome) as primary manifestation of a centrocytic-centroblastic lymphoma. Neurology 236: 168–169, 1989

    Article  CAS  Google Scholar 

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Correspondence to J. J. Heimans.

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Heimans, J.J., Wijermans, P.W., Polman, C.H. et al. Longterm meningeal involvement as the only clinical manifestation of low grade malignant non-Hodgkin's lymphoma. J Neuro-Oncol 9, 275–277 (1990). https://doi.org/10.1007/BF02341158

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Key words

  • low-grade non-Hodgkin's lymphoma
  • leptomeningeal involvement