Abstract
We report for the first time on the cytogenetics of a radiation-induced meningioma, in a patient without neurofibromatosis. Chromosome 22 monosomy was found in more than 50% of the cells examined. These findings seem to suggest that the same kind of chromosomal aberrations are found in both “idiopathic” and radiation-induced meningiomas and that a common etiopathogenetic mechanism might be at work in meningiomas of whatever origin.
Sommario
Si riferisce per la prima volta nella letteratura sulla citogenetica di un meningioma post-radiazione in un paziente non affetto da neurofibromatosi. Una monosomia del cromosoma 22 è stata trovata in più del 50% delle cellule esaminate. Questi dati suggeriscono che sia i meningiomi idiopatici che quelli post-radiazioni mostrano lo stesso tipo di aberrazioni cromosomali, e quindi che un meccanismo eziopatogenetico comune è all'opera in meningiomi di qualsivoglia origine.
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Pagni, C.A., Canavero, S., Fiocchi, F. et al. Chromosome 22 monosomy in a radiation-induced meningioma. Ital J Neuro Sci 14, 375–379 (1993). https://doi.org/10.1007/BF02340725
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DOI: https://doi.org/10.1007/BF02340725