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Advances in Contraception

, Volume 5, Issue 1, pp 31–39 | Cite as

Functional status of the pituitary-adrenal axis during treatment of RU486 for termination of early pregnancy in combination with PGs in Chinese women

  • X. -L. Yang
  • X. -R. Wu
Article

Abstract

Six pregnant women (below 49 days of amenorrhea) desiring pregnancy termination received 600 mg RU486 orally in a single dosage and 1 mg PG-05 or ONO-802 as vaginal suppository 48 h afterward. Plasma cortisol, corticosterone, aldosterone and ACTH were monitored at -0.5, 1, 2, 4, 10, 24, 48, 72 h as well as during the first follow-up visit at the 8th day. Cortisol increased during the treatment and the values returned to the pretreatment level by the first follow-up visit. The changes of corticosterone were similar to those of cortisol. ACTH was also elevated within first 2 h and returned to the basal level at 48 h. There was no notable change in aldosterone during the treatment.

The results suggest that a compensation of the pituitary-adrenal function occurred during the treatment, which is probably associated with a decreased negative feedback mechanism of cortisol due to the antiglucocorticosteroid activity of RU486 at the hypothalamus level.

Keywords

Cortisol Aldosterone Avant Pregnancy Termination Early Pregnancy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Resumé

On a administré à 6 femmes enceintes (ayant moins de 49 jours d'aménorrhée) qui désiraient interrompre leur grossesse, par voie orale en une seule prise 600 mg de RU486 et, 48 heures après, un ovule vaginal de 1 mg de PG-05 ou de ONO-802. On a contrôlé les niveaux du cortisol, de la corticostérone, de l'aldostérone et de l'ACTH plasmatiques à -0, 5, 1, 2, 4, 10, 24, 48 et 72 heures, ainsi que lors de la première visite de suivi à 8 jours. Le niveau de cortisol s'était élevé pendant le traitment mais, au moment de la première visite de suivi, les valeurs étaient retombées au niveau relevé avant le traiment. Des changements analogues à ceux du cortisol ont été constatés pour la corticostérone. L'ACTH s'était également élevée pendant le deux premières heures pour revenir à son niveau de base après 48 heures. Aucun changement notable de l'aldostérone n'a été retrouvé pendant le traitement. Ces résultats suggèrent qu'une compensation de la fonction adrénalo-pituitaire s'est produite pendant le traitement, qui est probablement associée à une diminution du mécanisme de contre-réaction du cortisol due à l'action antiglycocorticostéroidale du RU486 au niveau de l'hypothalamus.

Resumen

Seis mujeres embarazadas (menos de 49 días de amenorrea) recibieron 600 mg de RU486 en dosis única por vía oral y 1 mg de PG-05 u ONO-802 en forma de supositorio vaginal 48 horas más tarde. El cortisol, costicosterona, aldosterona y ACTH plasmáticos fueron controlados a las -0.5, 1, 2, 4, 10, 24, 48 y 72 horas así como durante la primer visita de seguimiento al octavo día. El cortisol aumentó durante el tratamiento y los valores volvieron a los niveles de antes del tratamiento hacia la primer visita de seguimiento. Los cambios de corticosterona fueron similares a los del cortisol. El ACTH también aumentó dentro de las dos primeras horas y volvió al nivel basal a las 48 horas. No hubo cambio notable en la aldosterona durante el tratamiento.

Los resultados sugieren que una compensación de la función pituitario-adrenal ocurrió durante el tratamiento la que probablement está asociada con una disminución en el mecanismo de retroalimentación de cortisol debido a la actividad antigluco-corticoesteroidea del RU486 a nivel hipotalámico.

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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • X. -L. Yang
    • 1
  • X. -R. Wu
    • 1
  1. 1.Family Planning Research InstituteTongji Medical UniversityWuhan, HubeiChina

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