Cortico-cortical connections, non-lnear multicolumnar parallel distributed networks and memory processes in humans. A review

  • Zappoli R. 


This review outlines the knowledge gained in the last 50 years concerning the neuroanatomy and neuro-psychophysiology of memory processes in humans. The first part traces the history of the most important findings from ablations of specific cerebral structures and/or stimulations performed on numerous patients using different surgical and neurophysiological methodologies. The interpretation of these findings is discussed. The most recent hypotheses on the neuronal substrates likely to be involved in memory and recall processes are then presented. In particular the concept of parallel distributed non-linear multicolumnar cortical networks is described as well as the recent hypothesis concerning the chaotic oscillatory properties of these complex non-linear neuronal systems which are said to behave as chaotic deterministic attractors.

Key Words

Human memory processes anatomofunctional memory substrates parallel distributed networks chaotic oscillatory properties 


Questa rivista sintetica riassume oltre ai dati di più recente acquisizione, i principali risultati degli ultimi 50 anni in tema di studi di neuroanatomia e neuro-psicofisiologia dei processi mnemonici nell'uomo.

Nella prima parte vengono brevemente descritti e discussi i principali risultati ottenuti con ablazioni e/o stimolazioni di specifiche formazioni cerebrali, in prevalenza corticali, in numerosi pazienti utilizzando differenti metodologie chirurgiche e neurofisiologiche.

Segue una sintesi delle più recenti ipotesi sulle caratteristiche anatomofunzionali dei substrati neuronali verosimilmente coinvolti nei differenti processi di fissazione e rievocazione dei cosiddetti engrammi. In particolare vengono illustrati il concetto di rete neuronale multicolonnare essenzialmente corticale distribuita in parallelo non stazionaria ed a dinamica non lineare e la recente ipotesi sulle proprietà oscillatorie caotiche di questi complessi sistemi neuronali non lineari che si comportano come attrattori caotici deterministici.


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  1. [1]
    Angeleri F., Ferro-Milione F., Parigi S.:Electrical activity and reactivity of the rhinencephalic, pararhinencephalic, and thalamic structures: prolonged implantation of electrodes in man. Electroencephalogr. Clin. Neurophysiol. 16: 100–129, 1964.PubMedGoogle Scholar
  2. [2]
    Barcaro V., Denoth F., Navona C., Zappoli R.:A study of the surface wave propagation in the CNV. In: Proceedings VI Mediterranean Conference on Medical and Biological Engineering. Bracale M., Brnoth F. (Eds.), I.E.I. CNR, Pisa 201–204, 1992.Google Scholar
  3. [3]
    Ba§ar E.:Chaotic dynamics and resonance phenomena in brain function: progress, perspectives and thoughts. In: Chaos In Brain Function, E. Ba§ar and T.H. Bullock (Eds.), Springer, Berlin, 1–31, 1990.Google Scholar
  4. [4]
    Bickford R.G., Mulder D.W., Dodge H.W., et al.:Changes in memory functions produced by electrical stimulation of the temporal lobe in man. Res. Pub. Ass. Nerv. Ment. Dis. 36: 227–243, 1958.Google Scholar
  5. [5]
    Glickstein M.:Neurofisiologia dell'apprendimento e della memoria. In: Fisiologia e Biofisica di Fulton-Howell. Vol. 1, Cap. XXIV, Società Editrice Universo, Roma, 1977.Google Scholar
  6. [6]
    Gloor P.:Experiential phenomena of temporal lobe epilepsy. Facts and hypotheses. Brain 113: 1673–1694, 1990.Google Scholar
  7. [7]
    Gloor P., Olivier A., Quesney L.f., et al.:The role of the limbic system in experiential phenomena of temporal lobe epilepsy. Ann. Neurol. 12: 129–144, 1982.CrossRefPubMedGoogle Scholar
  8. [8]
    Goldman-Rakic P.S.:Topography of cognition: parallel distributed networks in primate association cortex. Ann. Rev. Neurosci. 11: 137–156, 1988.PubMedGoogle Scholar
  9. [9]
    Halgren E., Walter R.D., Cherlow D.G., Crandall P.H.:Mental phenomena evoked by electrical stimulation of the human hippocampal formation and amygdala. Brain 101: 83–117, 1978.PubMedGoogle Scholar
  10. [10]
    Hermann B.P., Wyler A.R., Somes G.:Language function following anterior temporal lobectomy. J. Neurosurg. 74: 560–566, 1991.PubMedGoogle Scholar
  11. [11]
    Hillyard S.:The CNV and Human Behaviour. A Review. Electroencephalogr. Clin. Neurophysiol., Suppl. 33: 161–171, 1973.Google Scholar
  12. [12]
    Kutas M., Hillyard S.A., Gazzaniga M.S.:Processing of semantic anomaly by right and left hemispheres of commissurotomy patients, Evidence from event-related brain potentials. Brain 111: 553–576, 1988.PubMedGoogle Scholar
  13. [13]
    Ladavas E.:Il sistema esecutivo centrale ed i lobi frontali. Boll. Lega It. Epil. 66/67: 97–101, 1989.Google Scholar
  14. [14]
    Lopes da Silva F.:Neural mechanisms underlying brain waves: from neural membranes to networks-Review article. Electroencephalogr. Clin. Neurophysiol. 79: 81–93, 1991.PubMedGoogle Scholar
  15. [15]
    Milner B.:Visual recognition and recall after right temporal lobe excision in man. Neuropsychologia 6: 191–209, 1968.Google Scholar
  16. [16]
    Morrell R.:Electrophysiological Contributions to the Neural Basis of Learning. Physiological Reviews 41: 443–494, 1961.PubMedGoogle Scholar
  17. [17]
    Obrador S.:Temporal Lobotomy. J. Neuropathol. Exper. Neurol. 6: 185–193, 1947.Google Scholar
  18. [18]
    Pampiglione G., Falconer M.:Electrical stimulation of the hippocampus in man. Handbook of Physiology, Sec. I; Neurophysiology, American Physiological Society, Washington, Vol. 2, 1960.Google Scholar
  19. [19]
    Petrides M., Pandya D.N.:Association fiber pathways to the frontal cortex from the superior temporal region in the Rhesus Monkey. J. Compar. Neurol. 273: 52–66, 1988.CrossRefGoogle Scholar
  20. [20]
    Penfield W., Jasper H.:Epilepsy and the Functional Anatomy of the Human Brain. Little-Brown, Boston, 1954.Google Scholar
  21. [21]
    Penfield W., Milner B.:Memory deficit produced by bilateral lesions in the hippocampal zone. Arch. Neurol. Psychiat. 79: 475–499, 1958.Google Scholar
  22. [22]
    Penfield W., Perot P.:The brain's record of auditory and visual experience. A final summary and discussion. Brain 86: 595–696, 1963.PubMedGoogle Scholar
  23. [23]
    Petit-Dutaillis D., Christope J., Pertuiset B., et al.:Lobectomie temporale bilatérale pour épilepsie. Evolution des perturbations functionnelles postopératoires. Rev. Neurol. 91: 129–133, 1954.PubMedGoogle Scholar
  24. [24]
    Rumelhart D.E., McClelland J.L.:Parallel Distributed Processing: Explorations in the Microstructure of Cognition. Foundations, Vol. 1, MIT Press, Cambridge-London, 1986.Google Scholar
  25. [25]
    Scoville W., Milner B.:Loss of recent memory after bilateral hippocampal lesions. J. Neurol. Neurosurg. Psychiatry 20: 11–21, 1957.PubMedGoogle Scholar
  26. [26]
    Sem-Jacobsen C.:Depth Electrographic stimulation of the human brain and behaviour. Thomas, Springfield, 1968.Google Scholar
  27. [27]
    Terzian H., Dalle Ore G.:Syndrome of Klüver and Bucy reproduced in man by bilateral removal of the temporal lobes. Neurology (Minn.) 5: 373–380, 1955.Google Scholar
  28. [28]
    Zappoli R., Schergna E.:Le derivazioni basali nell'epilessia temporale. Considerazioni elettroanatomo-cliniche. Rass. Stud. Psichiat. XLIV: 3–51, 1955.Google Scholar
  29. [29]
    Zappoli R., Versari A.:Applications of bitmapped “cognitive” potentials (ERPs) in clinical neurophysiology. CNV complex in patients with destruction of the dorso-anteromedial bidirectional thalamo-prefrontal pathways. Ital. J. Neurol. Sci. 11: 339–344, 1990.PubMedGoogle Scholar
  30. [30]
    Zappoli R., Versari A.:I potenziali evento-correlati o cognitivi in neurofisiologia clinica. Considerazioni metodologiche ed interpretative. Riv. It. EEG Neurofisiol. Clin., Vol. 13: 113–126, 1990.Google Scholar
  31. [31]
    Zappoli R., Versari A., Arnetoli G., et al.:Bit-mapped cognitive potentials in patients with deafferentation or destruction of multimodal prefrontal cortical areas. In: Biological Psychiatry, Vol. 2, Int. Congr. Ser. 968. Excerpta Medica, Amsterdam, 419–422, 1991.Google Scholar
  32. [32]
    Zola-Morgan S., Squire L.R., Amaral D.G.:Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA 1 of the hippocampus. J. Neurosci. 6: 2950–2967, 1986.PubMedGoogle Scholar

Copyright information

© Masson Italia Editori 1993

Authors and Affiliations

  • Zappoli R. 
    • 1
  1. 1.Dipartimento di Scienze Neurologiche e PsichiatricheUniversità di FrienzeFirenze

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