Abstract
The case of a young woman with EPCK is described in which neoplastic and vascular disorders were excluded. Supported by EEG and PET, EPCK was imputed to multifocal encephalitis notwithstanding serological and CSF negativity. Cerebral biopsy confirmed the inflammatory nature of the affection, although the etiologic agent was not identified. High dose intravenous immunoglobulin therapy was followed by the prompt disappearance of EPCK and the remission of the other neurological deficits.
Sommario
Viene descritto un caso di EPCK nel quale era stata esclusa una patologia neoplastica o vascolare dell'encefalo. L'EPCK è stata attribuita ad una encefalite multifocale, che ha trovato sostegno nei reperti EEG e PET, nonostante la negatività delle indagini sierologiche e liquorali. Una biopsia cerebrale ha confermato la natura flogistica dell'affezione, senza identificarne l'agente etiologico. La somministrazione endovenosa di immunoglobuline ad alto dosaggio è stata seguita da una rapida scomparsa della EPCK e da una remissione degli altri deficit neurologici.
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References
Aicardi J., Goutieres F., Arsenio-Nunes M.L., Lebon P.:Acute measles encephalitis in children with immunodepression. Pediatrics, 59:232–239, 1977.
Aguilar M.J., Rasmussen T.:Role of encephalitis in pathogenesis of epilepsy. Arch. Neurol., 2:663–676, 1960.
Bancaud J., Bonis A., Talairach J. et al.:Syndrome de Kojewnikow et accéss somatomotéurs (étude clinique, EEG, EMG, SEEG). Encephale, 59:391–438, 1970.
Bancaud J., Bonis A., Trottier S. et al.:L'épilepsie partielle continue: syndrome et maladie. Rev. Neurol., 138:803–814, 1982.
Bhatia K., Thompson P.D., Marsden C.D.:“Isolated” postinfectious myoclonus. J. Neurol. Neurosurg. Psychiatry, 55:1089–1091, 1992.
Booss J., Esiri M.M.:Viral encephalitis. Pathology, diagnosis and management. Blackwell, Oxford, 1986.
Cervós Navarro J., Ferszt R.:Neuropatologia Clinica, Bi & Gi Editori, Verona, 1992.
Chevrier J.J., Aicardi J., Goutieres F.:Epilepsy in childhood mitochondrial myopathies. In: “Advances in Epileptology. XVI Epilepsy International Symposium,” Raven Press: New York, 1986.
Commission on Classification and Terminology of the International League Against Epilepsy.Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia, 30:389–399, 1989.
Delgado-Escueta A.V., Schwartz B., Abad-Herrera P.:Status epilepticus. In: (eds.) Dam M., Gram L.: “Comprehensive Epileptology”, Raven Press: New York, 251–270, 1990.
Gray F., Serdaru M., Baron H. et al.:Chronic localized encephalitis (Rasmussen's) in an adult with epilepsia partialis continua. J. Neurol. Neurosurg. Psychiatry, 50:747–751, 1987.
Kozhevnikov A. Ya.:A particular type of cortical epilepsy (epilepsia corticalis sive partialis continua). In: (ed.) Andermann F.: Chronic encephalitis and epilepsy, Rasmussen's syndrome. Butterworths-Heinemann, pp. 245–261, 1991.
Kuzniecky R., Berkovic S., Andermann F. et al.:Focal cortical myoclonus and rolandic cortical dysplasia: clarification by magnetic resonance imaging. Ann. Neurol. 23, 4:317–325, 1988.
Juul-Jennsen I., Denny-Brown D.:Epilepsia partialis continua. Arch. Neurol., 23–29, 1966.
Laplane D., Widlocker D., Pillon B. et al.:Comportement compulsif d'allure obsessionelle par nécrose circonscrite bilatérale pallido-striatale. Rev. Neurol. 137, 4:269–276, 1981.
Montagna P., Gallassi R., Medori R. et al.:MELAS syndrome: characteristic migraneous and epileptic features and maternal transmission. Neurology, 38:751–754, 1988.
Oguni H., Andermann F., Rasmussen Th.B.:The natural history of the syndrome of chronic encephalitis and epilepsy: A study of the M.N.I. series of 48 cases. In: (ed.) Andermann F.: Chronic encephalitis and epilepsy. Butterworths-Heinemann, pp. 7–36, 1991.
Robitaille Y.:Neuropathologic aspects of chronic encephalitis. In: Andermann Fed.: Chronic encephalitis and epilepsy. Butterworths-Heinemann, pp. 79–110, 1991.
Shibasaki H., Kuroiwa Y.:Electroencephalographic correlates of myoclonus. Electroencephalogr. Clin. Neurophysiol., 39:455–463, 1975.
Thomas J.E., Reggan T.J., Klass D.W.:Epilepsia partialis continua. A revue of 32 cases. Arch. Neurol., 34:266–275, 1977.
Walsh P.J.:Treatment of Rasmussen's syndrome with intravenous gammaglobulin. In: (ed.) Andermann F.: Chronic encephalitis and epilepsy. Butterworths-Heinemann, pp. 201–204, 1991.
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Barontini, F., Maurri, S. & Amantini, A. “Epilepsia partialis continua” due to multifocal encephalitis: Favourable outcome after immunoglobulin treatment. Ital J Neuro Sci 15, 157–161 (1994). https://doi.org/10.1007/BF02339208
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DOI: https://doi.org/10.1007/BF02339208