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Toxic effect of intraventricular interferon-alpha in subacute sclerosing panencephalitis


Intraventricular interferon (IFN) administration has been shown to improve the course of SSPE. However, in 2 patients treated with intraventricular IFN-α-2a over a long period, we observed the appearance of clinical and EMG signs suggestive of upper and lower motor neuron pathology. These signs improved slightly in one patient after the discontinuation of IFN. It is suggested that this polypeptide may act on specific kinds of nervous cells which selectively suffer together in various well-known neurological diseases.


La somministrazione intraventricolare di interferon (IFN) è stata vista migliorare il decorso della panencefalite sclerosante subacuta. Tuttavia, in 2 pazienti trattati con IFN-alfa-2a per un lungo periodo, noi abbiamo osservato la comparsa di segni clinici ed EMG suggestivi di una patologia del motoneurone superiore e inferiore. Tali segni migliorarono leggermente in un paziente dopo sospensione della terapia con IFN. Si suggerisce che questo polipeptide possa esercitare un'azione su uno specifico tipo di cellule nervose che selettivamente soffrono insieme in diverse ben note affezioni neurologiche.

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Cianchetti, C., Fratta, A.L., Muntoni, F. et al. Toxic effect of intraventricular interferon-alpha in subacute sclerosing panencephalitis. Ital J Neuro Sci 15, 153–155 (1994).

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