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Journal of Molecular Evolution

, Volume 43, Issue 3, pp 312–314 | Cite as

A new transmembrane 4 superfamily molecule in the nematode,Caenorhabditis elegans

  • Michael G. Tomlinson
  • Mark D. Wright
Letter to the Editor

Abstract

Transmembrane 4 superfamily (TM4SF) molecules are predominantly mammalian cell surface glycoproteins that are thought to transduce signals mediating cell development, activation, and motility. Analysis of the Genpept sequence database reveals YKK8, a novel member of the TM4SF in the nematode,Caenorhabditis elegans. YKK8 is a putative 27.4-kDa protein encoded by a gene on chromosome III of theC. elegans genome (Wilson et al. [1994]Nature 368:32–38). The assignment of YKK8 to the TM4SF is justified by three criteria: statistical comparison of protein sequences, conserved TM4SF protein sequence motifs, and conserved TM4SF intron/exon boundaries in the genomic sequence. The discovery of a TM4SF molecule in the nematode extends this superfamily to a more primitive branch of the phylogenetic tree and suggests a fundamental role for TM4SF molecules in biology.

Key words

Transmembrane 4 superfamily YKK8 Caenorhabditis elegans 

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Copyright information

© Springer-Verlag New York Inc 1996

Authors and Affiliations

  • Michael G. Tomlinson
    • 1
  • Mark D. Wright
    • 2
  1. 1.MRC Cellular Immunology Unit, Sir William Dunn School of PathologyUniversity of OxfordOxfordEngland
  2. 2.The Walter and Eliza Hall Institute of Medical ResearchPost Office RMHVictoriaAustralia

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