The Italian Journal of Neurological Sciences

, Volume 12, Issue 6, pp 581–584 | Cite as

Genetic transmission of migraine without aura: A study of 68 families

  • D'Amico D. 
  • Leone M. 
  • Macciardi F. 
  • Valentini S. 
  • Bussone G. 
Original Articles


68 randomly selected patients with migraine without aura (M) and 4 generations of their relatives (N=394) were studied in order to probe the genetic hypothesis of migraine. Significantly more of the probands were women and M was significantly more frequent among female relatives. Earlier onset was commoner among male probands. A genetic component of M is indicated by the very high frequency of at least one affected relative (85.3%) and by a disease prevalence that is similar among both first and second degree relatives. A simple autosomal mode of transmission seems unlikely from analysis of the data on the affected relatives, while a “sex-limited” transmission mode is suggested.

Key Words

Migraine without aura genetic hypothesis family history “sex-limited” transmission 


Allo scopo di comprovare la teoria genetica dell'emicrania, abbiamo studiato 68 pazienti consecutivi affetti da emicrania senz'aura insieme ai loro parenti attraverso quattro generazioni (N=394). Significativamente la maggior parte dei probandi erano donne e l'emicrania era più frequente tra i parenti di sesso femminile.

Un'età di esordio più bassa era più comune tra i probandi di sesso maschile. L'esistenza di una componente genetica dell'emicrania senz'aura è indicata dall' alta incidenza di storia familiare positiva (almeno un parente affetto) uguale all'85.3% e da una costante prevalenza di malattia nei parenti di primo e secondo grado.

Dall'analisi dei dati riguardanti le percentuali di probandi con genitori affetti da emicrania, sembra improbabile l'esistenza di una trasmissione di tipo autosomico. Viene proposta una trasmissione “sex-limited”.


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Copyright information

© Masson Italia Periodici S.r.l. 1991

Authors and Affiliations

  • D'Amico D. 
    • 1
  • Leone M. 
    • 1
  • Macciardi F. 
    • 2
  • Valentini S. 
    • 1
  • Bussone G. 
    • 1
  1. 1.Centro CefaleeIstituto Nazionale Neurologico, “C. Besta”Milano
  2. 2.Clinica Psichiatrica IIIUniversità di Milano, Ospedale San RaffaeleMilanoItaly

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