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The cerebrospinal fluid tau-transferrin. Isoelectric focusing study on 674 neurological patients

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Abstract

The frequency of the two tau-fractions in isoelectric focusing examination of cerebrospinal fluid proteins has been studied in 674 neurological patients.

The double tau-fraction was found in 151 patients (22.4%); this finding was not characteristically associated with any particular disease, but its frequency was high in hereditary diseases (13 cases out of 30; 43.3%), mainly Charcot-Marie-Tooth's disease.

Sommario

La frequenza della comparsa di una frazione tau sdoppiata in due bande all'esame delle proteine del liquido cerebrospinale con isoelettofocalizzazione è stata studiata in un gruppo di 674 malati neurologici.

Tale reperto è stato riscontrato in 151 casi (22,4%); non è risultato caratteristicamente associabile a una qualche singola entità morbosa ma è apparso significativamente più frequente nel gruppo dei pazienti con affezioni eredo-degenerative (13 casi su 30; 43,3%), ed in particolare, con malattia di Charcot-Marie-Tooth.

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References

  1. Bücher, T., Matzelt, D., Pette, D.:Papierelektrophorese von Liquor cerebrospinalis. Klin. Wschr. 30: 325–330, 1952.

    Article  PubMed  Google Scholar 

  2. Clausen, J., Munkner, T.:Transferrin in normal cerebrospinal fluid. Nature (London), 189: 60–61, 1961.

    Article  CAS  Google Scholar 

  3. Fossard, C., Dale, G., Latner, A.:Separation of proteins of cerebrospinal fluid using gel electrofocusing followed by electrophoresis. J. Clin. Path., 23: 586–589, 1970.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Jersild, C., Svejgaard, A., Fog, T.:HL-A antigens associated with multiple sclerosis. Lancet, I: 1242–1243, 1972.

    Google Scholar 

  5. Kjellin, K.G., Versterberg O.:Isoelectric focusing of CSF proteins in neurological diseases. J. Neurol. Sci., 23: 199–213, 1974.

    Article  CAS  PubMed  Google Scholar 

  6. Kjellin, K.G., Stibler, H.:Protein pattern of cerebro-spinal fluid in spasmodic torticollis. J. Neurol. Neurosurg, Psychiat., 37: 1128–1132, 1974.

    Article  CAS  Google Scholar 

  7. Kjellin, K.G., Stibler, H.:CSF protein patterns in extrapyramidal diseases. Europ. Neurol., 12: 186–194, 1974.

    Article  CAS  PubMed  Google Scholar 

  8. Kjellin, K.G., Stibler, H.:Protein patterns of cerebrospinal fluid in hereditary ataxias and hereditary spastic paraplegia. J. Neurol. Sci., 25: 65–74, 1975.

    Article  CAS  PubMed  Google Scholar 

  9. Kjellin, K.G., Stibler, H.:Isoelectric focusing and electrophoresis of cerebrospinal fluid proteins in muscular dystrophies and spinal muscular atrophies. J. Neurol. Sci., 27: 45–57, 1976.

    Article  CAS  PubMed  Google Scholar 

  10. Kühnl, P., Spielmann, W.:Transferrin: evidence for two common subtypes of the Tf C allele. Hum. Genet., 43: 91–95, 1978.

    Article  PubMed  Google Scholar 

  11. Link, H., Tibbling, G.:Principles of albumin and IgG analyses in neurological disorders: III Evaluation of IgG synthesis within the central nervous system in multiple sclerosis. Scand. J. Clin. Lab. Invest., 37: 397–401, 1977.

    Article  CAS  PubMed  Google Scholar 

  12. Livrea, P., Zimatore, G.B., Simone, I.L., Lepore, V., Troiano, M., Loreto, M., De Blasi, A., Gennarini, G.F.:Isoelectric focusing and crossed-immunoelectrofocusing of cerebrospinal fluid proteins in neurological disorders. Acta Neurol., 33: 501–507, 1978.

    CAS  Google Scholar 

  13. Lowry, O.H., Rosebrough, A., Farr, A.L., Randall, R.J.:Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193: 265–275, 1951.

    CAS  PubMed  Google Scholar 

  14. Oosterhuis, H.G., Feltkamp, T.E.W., Van Rassum, A.L., Van Den Berg-Loonen, P.M., Nijenhuis, L.E.:HL-A antigens, autoantibody production and associated diseases in thymoma patients, with and without mysthenia gravis. Ann. N.Y. Acad. Sci., 274: 468–474, 1976.

    Article  CAS  PubMed  Google Scholar 

  15. Parker, C., Bearn, A.:Studies on the transferrins of adult serum, cord serum and cerebrospinal fluid. J. Exp. Med., 115: 83–105, 1962.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Pedersen, L., Platyz, P., Jersild, C., Thomsen, M.:HLA (SD and LD) in patients with amyotrophic lateral sclerosis (ALS). J. Neurol, Sci., 31: 313–318, 1977.

    Article  CAS  Google Scholar 

  17. Pette, D., Stupp, I.:Die Tau-Fraktion in Liquor Cerebrospinalis. Klin. Wschr., 38: 109–110, 1960.

    Article  CAS  PubMed  Google Scholar 

  18. Schliep, G., Felgenhauer, K.:Serum-CSF protein gradients, the blood-CSF barrier and the local immune response. J. Neurol., 218: 77–96, 1978.

    Article  CAS  PubMed  Google Scholar 

  19. Stibler, H.:The normal cerebrospinal fluid proteins identified by means of thin-layer isoelectric focusing and crossed immunoelectrofocusing. J. Neurol. Sci., 36: 273–288, 1978.

    Article  CAS  PubMed  Google Scholar 

  20. Stibler, H.:Isoelectric focusing of the cerebrospinal fluid proteins in degenerative diseases of the central nervous sistem. Thesis, Karolinska Institute, Stockholm, 1978.

    Google Scholar 

  21. Stibler, H.:Direct immunofixation after isoelectric focusing: an improved method for identification of cerebrospinal fluid and serum proteins. J. Neurol. Sci., 42: 275–281, 1979.

    Article  CAS  PubMed  Google Scholar 

  22. Stibler, H., Beckman, G., Sikstrom, C.:Subtypes of transferrin C. Hum. Hered., 29: 320–324, 1979.

    Article  CAS  PubMed  Google Scholar 

  23. Thymann, M.:Identification of a new serum protein polymorphism as transferrin. Hum. Genet., 43: 225–229, 1978.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Clinica Neurologica-Università di Pavia, Via Palestro 3, 27100, Pavia, Italia

    Rocchelli B., Poloni M., Delodovici M., Mazzarello P. & Cosi V.

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  1. Rocchelli B.
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  2. Poloni M.
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  3. Delodovici M.
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  4. Mazzarello P.
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  5. Cosi V.
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Rocchelli, B., Poloni, M., Delodovici, M. et al. The cerebrospinal fluid tau-transferrin. Isoelectric focusing study on 674 neurological patients. Ital J Neuro Sci 1, 251–255 (1979). https://doi.org/10.1007/BF02336706

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  • DOI: https://doi.org/10.1007/BF02336706

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