The Italian Journal of Neurological Sciences

, Volume 11, Issue 4, pp 359–366 | Cite as

Neuron specific enolase (NSE) and thymidine kinase (TK) as markers in biological fluids of brain tumor patients

  • Boiardi A. 
  • Munari L. 
  • Silvani A. 
  • Solero C. L. 
  • Bombardieri E. 
Original Articles
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Abstract

We studied the activity of two enzymes NSE and TK in the biological fluids of 104 patients with nervous system diseases, who fell into 4 groups. 20 subjects out of 35 in the tumor group had glial tumors. We fixed a cut-off value of NSE and TK activity at the 95th percentile of the control group, both in serum and in CSF. The aim of our investigation was to assess the reliability of TK and NSE assays in separating brain tumors from other neurological diseases. In our patients, most of the TK activity above the cut-off value was found in the tumor group. Serum TK seems to be a useful marker for following up cerebral tumors after surgery, but NSE is less useful for this purpose.

Key-Words

Thymidine kinase neuron specific enolase markers brain tumor 

Sommario

Abbiamo studiato l'attività di due enzimi NSE e TK nei liquidi biologici di 104 Pazienti affetti da patologie del sistema nervoso. I Pazienti sono stati divisi in quattro gruppi: dei 35 Pazienti affetti da neoplasie 20 erano portatori di un tumore della serie gliale.

Su liquor e su siero il valore cut-off dell'attività di NSE e TK è stato fissato al 95o percentile del gruppo controllo. Lo scopo del nostro studio è stato quello di stabilire la affidabilità del dosaggio della NSE e della TK nel separare i tumori cerebrali da altre patologie d'interesse neurologico. Nei nostri Pazienti la maggiore attività enzimatica al di sopra del valore cut-off è stata riscontrata nel gruppo tumorale.

I livelli serici di TK sembrano essere un utile marker per la valutazione del follow-up post-chirurgico dei Pazienti affetti da tumore gliale, mentre la valutazione dei valori della NSE non sembra utile a tale scopo.

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Copyright information

© Masson Italia periodici s.r.l. 1990

Authors and Affiliations

  • Boiardi A. 
    • 2
  • Munari L. 
    • 2
  • Silvani A. 
    • 2
  • Solero C. L. 
    • 2
  • Bombardieri E. 
    • 1
  1. 1.Istituto Nazionale TumoriMilano
  2. 2.Istituto Nazionale Neurologico “C. Besta”Milano

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