Abstract
A longitudinal clinical neurological and electrophysiological follow-up study was carried out on 31 HIV1 seropositive outpatients in the asymptomatic or LAS stages of the infection (CDC II–III).
The results of clinical examination and multimodal evoked potentials (EP) recording showed a high percentage of abnormalities (42% and 39% of cases respectively); in a statistically significant number of subjects these abnormalities were predictive of subsequent immunological deterioration, thus demonstrating the close relationship between neurological and immunological functions in HIV1 infection.
Sommario
Abbiamo eseguito uno studio longitudinale di follow-up neurologico clinico ed elettrofisiologico su 31 pazienti ambulatoriali sieropositivi per anticorpi anti-HIV1, in stadio di infezione asintomatica o di LAS (CDC II–III). I risultati dell'esame clinico e della registrazione dei potenziali evocati multimodali hanno mostrato una elevata percentuale di alterazioni (rispettivamente nel 42% e nel 39% dei soggetti); in un numero di casi statisticamente significativo tali anomalie si sono rivelate predittive di un successivo peggioramento della situazione immunologica, mettendo così in evidenza la stretta correlazione tra stato neurologico ed immunologico nel corso dell'infezione da HIV1.
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Supported by Istituto Superiore di Sanità/Ministero della Sanità, II AIDS Research Project-1989.
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Tilia, G., Spadaro, M., Soldati, G. et al. Predictive value of neurological abnormalities in HIV 1 patients in the early stages of the infection. Ital J Neuro Sci 14, 171–177 (1993). https://doi.org/10.1007/BF02335752
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DOI: https://doi.org/10.1007/BF02335752