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Antiphospholipid antibodies syndrome and cerebral ischemia

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Abstract

Antiphospholipid antibodies are acquired circulating immunoglobulins that interact with phospholipids. These factors may manifest anticoagulant properties in vitro, interfering with phospholipid-dependent coagulation tests. They are not, however, associated with a hemorrhagic diathesis. Indeed, far from exerting the anticoagulant properties they possess in vitro, they are associated with episodes of thromboembolism, systemic and cerebral. We report the clinical and instrumental findings in 7 patients with ischemic stroke and circulating antiphospholipid antibodies classifiable as antiphospholipid antibodies syndrome.

Sommario

Gli anticorpi antifosfolipidi sono immunoglobuline circolanti acquisite che interagiscono con i fosfolipidi. Questi fattori, in vitro, possono manifestare proprietà anticoagulanti interferendo con i test della coagulazione fosfolipidi-dipendenti. Tali anticorpi non sono tuttavia associati a diatesi emorragica. Infatti, contrariamente alle loro proprietà anticoagulanti in vitro, essi sono correlati ad episodi tromboembolici sistemici e cerebrali.

Vengono descritti i reperti clinici e strumentali osservati in sette pazienti con ictus ischemico ed anticorpi antifosfolipidi in circolo, inquadrabili nella sindrome da anticorpi antifosfolipidi.

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References

  1. Asherson R.A.:A “primary” antiphospholipid syndrome? J. Rheumatol. 15:1742–1746, 1988.

    CAS  PubMed  Google Scholar 

  2. Asherson R.A., Khamashta M.A., Gil A.G. et al.:Cerebrovascular disease and antiphospholipid antibodies in systemic lupus erythematosus, lupus-like disease, and the primary antiphospholipid syndrome. Am. J. Med. 86:391–399, 1989.

    Article  CAS  PubMed  Google Scholar 

  3. Asherson R.A., Mercey D., Phillips G. et al.:Recurrent stroke and multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies. Ann. Rheum. Dis. 46:605–611, 1987.

    CAS  PubMed  Google Scholar 

  4. Bernard C., de Moerloose P.:Anticorps anticardiolipine et thromboses. Med. et Hyg. 48:166–169, 1990.

    Google Scholar 

  5. Blatt P.M., Martin S.E.:The lupus anticoagulant. Arch. Pathol. Lab. Med. 111:113–114, 1987.

    CAS  PubMed  Google Scholar 

  6. Bloom E.J., Abrams D.I., Rodgers G.:Lupus anticoagulant in the acquired immunodeficiency syndrome. J.A.M.A. 256:491–493, 1986.

    CAS  PubMed  Google Scholar 

  7. Brey R.L., Hart R.G., Sherman D.G., Tegeler C.H.:Antiphospholipid antibodies and cerebral ischemia in young people. Neurology 40:1190–1196, 1990.

    CAS  PubMed  Google Scholar 

  8. Briley D.P., Coull B.M., Goodnight S.H. Jr.:Neurological diseases associated with antiphospholipid antibodies. Ann. Neurol. 25:221–227, 1989.

    Article  CAS  PubMed  Google Scholar 

  9. Couley C.L., Hartmann R.C.:A hemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus. J. Clin. Invest. 31:621–622, 1952.

    Google Scholar 

  10. Coull B.M., Bourdette D.N., Goodnight S.H. et al.:Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies. Stroke 18:1107–1112, 1987.

    CAS  PubMed  Google Scholar 

  11. Coull B.M., Goodnight S.H.:Antiphospholipid antibodies, prethrombotic states, and stroke. Stroke 21:1370–1374, 1990.

    CAS  PubMed  Google Scholar 

  12. Digre K.B., Durcan F.J., Branch D.W. et al.:Amaurosis fugax associated with antiphospholipid antibodies. Ann. Neurol. 25:228–232, 1989.

    Article  CAS  PubMed  Google Scholar 

  13. Elias M., Eldor A.:Thromboembolism in patients with the “lupus”-type circulating anticoagulant. Arch. Intern. Med. 144:510–515, 1984.

    Article  CAS  PubMed  Google Scholar 

  14. Ford P.M., Brunet D., Lillicrap D., Ford S.:Premature stroke in a family with lupus anticoagulant and antiphospholipid antibodies. Stroke 21:66–71, 1990.

    CAS  PubMed  Google Scholar 

  15. Futrell N., Millikan C.:Frequency, etiology, and prevention of stroke in patients with systemic lupus erythematosus. Stroke 20:583–591, 1989.

    CAS  PubMed  Google Scholar 

  16. Hart R.G., Kanter M.C.:Hematologic disorders and ischemic stroke. A selective review. Stroke 21:1111–1121, 1990.

    CAS  PubMed  Google Scholar 

  17. Hering R., Couturier E.G.M., Steiner T.J. et al.:Anticardiolipin antibodies in migraine. Cephalalgia 11:19–22, 1991.

    CAS  PubMed  Google Scholar 

  18. Hughes G.R.V.:Thrombosis, abortion, cerebral disease, and the lupus anticoagulant. Br. Med. J. 287:1088–1089, 1983.

    CAS  Google Scholar 

  19. Hughes G.R.V., Harris N.N., Gharavi A.G.:The anticardiolipin syndrome. J. Rheumatol. 13:481–488, 1986.

    Google Scholar 

  20. Inzelberg R., Korczyn A.D.:Lupus anticoagulant and late onset seizures. Acta Neurol. Scand. 79:114–118, 1989.

    CAS  PubMed  Google Scholar 

  21. Kalashnikova L.A., Nasonov E.L., Kushekbaeva A.E., Gracheva L.A.:Anticardiolipin antibodies in Sneddon's syndrome. Neurology 40:464–467, 1990.

    CAS  PubMed  Google Scholar 

  22. Kushner M.:Prospective study of anticardiolipin antibodies in stroke. Stroke 21:295–298, 1990.

    CAS  PubMed  Google Scholar 

  23. Kusner M., Simonian N.:Lupus anticoagulants, anticardiolipin antibodies, and cerebral ischemia. Stroke 20:225–229, 1989.

    Google Scholar 

  24. Lazarchick J., Kizer J.:The laboratory diagnosis of lupus anticoagulants. Arch. Pathol. Lab. Med. 113:177–180, 1989.

    CAS  PubMed  Google Scholar 

  25. Levine S.R., Welch K.M.A.:Cerebrovascular ischemia associated with lupus anticoagulant. Stroke 18:257–263, 1987.

    CAS  PubMed  Google Scholar 

  26. Levine S.R., Welch K.M.A.:The spectrum of neurologic diseases associated with antiphospholipid antibodies. Lupus anticoagulants and anticardiolipin antibodies. Arch. Neurol. 44:876–883, 1987.

    CAS  PubMed  Google Scholar 

  27. Lippi G., Alessandrello Liotta A., Cellai A.P. et al.:Anticorpi antifosfolipidi e loro implicazioni cliniche. Toscana Medica 9:28–30, 1991.

    Google Scholar 

  28. Nencini P., Matà S., Spolveri S. et al.:Anticardiolipin and antiphosphatidylinositol antibodies in acute ischemic stroke. Comunicazione presentata all'International Conference “Acute stroke: from basic research to new diagnostic and therapeutic tools’-Monza (Italy), March 12–14, 1992.

  29. Shapiro S., Thiagarajan P.:Lupus anticoagulants. Prog. Hemost. Thromb. 6:263–285, 1982.

    CAS  PubMed  Google Scholar 

  30. Shorer A.E., Wickham N.W.R., Watson K.V.:Lupus anticoagulant induces a selective defect in thrombin-mediated endothelial prostacyclin release and platelet aggregation. Br. J. Haematol. 71:399–407, 1989.

    Google Scholar 

  31. The Antiphospholipid Antibodies in Stroke Study Group:Clinical and laboratory findings in patients with antiphospholipid antibodies and cerebral ischemia. Stroke 21:1268–1273, 1990.

    Google Scholar 

  32. Triplett D.A., Brandt J.T., Musgrave K.A., Orr C.A.:The relationship between lupus anticoagulants and antibodies to phospholipid. J.A.M.A. 259:550–554, 1988.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. U.O. Neurologia/Neurofisiopatologia, Ospedale USL 23, Arezzo

    Severi S. & Ghezzi M.

  2. U.O. Medicina Interna I, Ospedale USL 23, Arezzo

    Felici M.

  3. Laboratorio Analisi, Ospedale USL 23, Arezzo

    Miele A.

Authors
  1. Severi S.
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  2. Ghezzi M.
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  3. Felici M.
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  4. Miele A.
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Additional information

Paper presented at the National Congress at Sorrento in 1991 and selected by the Editorial Board of the Journal

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Severi, S., Ghezzi, M., Felici, M. et al. Antiphospholipid antibodies syndrome and cerebral ischemia. Ital J Neuro Sci 14, 129–137 (1993). https://doi.org/10.1007/BF02335747

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