Abstract
Six patients with Steinert disease were treated with selenium and vitamin E, for a 24 month period, including a first phase of 12 months, 6 months wash-out interval and a second treatment phase of 6 months. Mean segmental strength values showed significant improvement during the first 12 months of therapy, while marked reductions of serum enzymes CPK, SGOT, SGPT and γ-GT were observed in some patients. The results support the hypothesis that selenium may play a role in the development of muscle damage in Steinert disease.
Sommario
Sei pazienti, affetti da malattia di Steinert, sono stati sottoposti a terapia con selenio e vitamina E per un periodo di 24 mesi, che ha incluso una prima fase di 12 mesi, un intervallo di “wash-out” di 6 mesi ed una seconda fase di trattamento di altri 6.
I valori medi di forza segmentaria mostrano un significativo aumento durante i primi 12 mesi di terapia, mentre in alcuni pazienti sono osservabili evidenti riduzioni dei livelli sierici degli enzimi CPK, SGOT, SGPT e γ-GT.
Tali risultati sostengono l'ipotesi che il selenio può rivestire un ruolo nello sviluppo del danno muscolare nella malattia di Steinert.
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Rossi, B., Siciliano, G., Risaliti, R. et al. Effects of selenium and vitamin E on muscular strength and blood parameters in Steinert disease. Ital J Neuro Sci 11, 37–42 (1990). https://doi.org/10.1007/BF02334903
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DOI: https://doi.org/10.1007/BF02334903